Chih-Wei Ko
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Explore the profile of Chih-Wei Ko including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
341
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Recent Articles
1.
Tremblay F, Xiong Q, Shah S, Ko C, Kelly K, Morrison M, et al.
Nat Med
. 2025 Feb;
PMID: 39930141
Epigenetic editing holds the promise of durable therapeutic effects by silencing disease-causing genes without changing the underlying DNA sequence. In this study, we designed an epigenetic editor to target human...
2.
Wang F, Ko C, Qu J, Wu D, Zhu Q, Liu M, et al.
Nutrients
. 2023 Nov;
15(22).
PMID: 38004234
Apolipoprotein A-IV (apoA-IV), synthesized by enterocytes, is potentially involved in regulating lipid absorption and metabolism, food intake, and glucose metabolism. In this study, we backcrossed apoA-IV knockout (apoA-IV) mice onto...
3.
Qu J, Wu D, Ko C, Zhu Q, Liu M, Tso P
Nutrients
. 2023 Nov;
15(21).
PMID: 37960308
Obesity is one of the main risk factors for cardiovascular diseases, type II diabetes, hypertension, and certain cancers. Obesity in women at the reproductive stage adversely affects contraception, fertility, maternal...
4.
Zhang S, Bastille A, Gordo S, Ramesh N, Vora J, McCarthy E, et al.
PLoS One
. 2022 Sep;
17(9):e0274774.
PMID: 36126056
Methylmalonic acidemia (MMA) is an inborn error of metabolism mostly caused by mutations in the mitochondrial methylmalonyl-CoA mutase gene (MMUT). MMA patients suffer from frequent episodes of metabolic decompensation, which...
5.
Ko C, Counihan D, DeSantis D, Sedor-Schiffhauer Z, Puchowicz M, Croniger C
Bio Protoc
. 2021 Aug;
8(17):e3003.
PMID: 34395796
Using gas chromatography mass spectrometry (GC-MS) to analyze the citric acid cycle (CAC) and related intermediates (such as glutamate, glutamine, GABA, and aspartate) is an analytical approach to identify unexpected...
6.
Chandler R, Venturoni L, Liao J, Hubbard B, Schneller J, Hoffmann V, et al.
Hepatology
. 2020 Sep;
73(6):2223-2237.
PMID: 32976669
Background And Aims: Adeno-associated viral (AAV) gene therapy has shown great promise as an alternative treatment for metabolic disorders managed using liver transplantation, but remains limited by transgene loss and...
7.
Ko C, Qu J, Black D, Tso P
Nat Rev Gastroenterol Hepatol
. 2020 Feb;
17(3):169-183.
PMID: 32015520
Lipids entering the gastrointestinal tract include dietary lipids (triacylglycerols, cholesteryl esters and phospholipids) and endogenous lipids from bile (phospholipids and cholesterol) and from shed intestinal epithelial cells (enterocytes). Here, we...
8.
Ko C, Qu J, Tso P
Am J Clin Nutr
. 2019 May;
109(6):1495-1496.
PMID: 31075794
No abstract available.
9.
Qu J, Ko C, Tso P, Bhargava A
Cells
. 2019 Apr;
8(4).
PMID: 30959835
Apolipoprotein A-IV (apoA-IV) is a lipid-binding protein, which is primarily synthesized in the small intestine, packaged into chylomicrons, and secreted into intestinal lymph during fat absorption. In the circulation, apoA-IV...
10.
Ko C, Qu J, Liu M, Black D, Tso P
Curr Protoc Mouse Biol
. 2019 Feb;
9(1):e60.
PMID: 30801996
This protocol provides a comprehensive reference for the evolution of the lymph fistula model, the mechanism of lipid absorption, the detailed procedure for studying lipid absorption using the lymph fistula...