Chien-Ping Liang
Overview
Explore the profile of Chien-Ping Liang including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
756
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Recent Articles
1.
Liang C, Han S, Li G, Tabas I, Tall A
Diabetes
. 2012 Jul;
61(10):2609-20.
PMID: 22751695
Accumulation of toxic lipids evokes the unfolded protein response (UPR) and apoptotic death of macrophages and vascular cells in atherosclerotic plaques. Primary macrophages from insulin-resistant ob/ob and insulin receptor (Insr)(-/-)...
2.
Tsuchiya K, Banks A, Liang C, Tabas I, Tall A, Accili D
Arterioscler Thromb Vasc Biol
. 2011 Sep;
31(12):2920-8.
PMID: 21940942
Objective: Insulin resistance renders macrophages more prone to cholesterol-induced apoptosis by promoting nuclear localization of transcription factor forkhead box transcription factor (Fox) O1. However, FoxO1 also decreases macrophage inflammation, raising...
3.
Li Z, Zhang H, Liu J, Liang C, Li Y, Li Y, et al.
Mol Cell Biol
. 2011 Aug;
31(20):4205-18.
PMID: 21844222
It has been shown that inhibition of de novo sphingolipid synthesis increases insulin sensitivity. For further exploration of the mechanism involved, we utilized two models: heterozygous serine palmitoyltransferase (SPT) subunit...
4.
Li S, Sun Y, Liang C, Thorp E, Han S, Jehle A, et al.
Circ Res
. 2009 Oct;
105(11):1072-82.
PMID: 19834009
Rationale: The complications of atherosclerosis are a major cause of death and disability in type 2 diabetes. Defective clearance of apoptotic cells by macrophages (efferocytosis) is thought to lead to...
5.
Han S, Liang C, Westerterp M, Senokuchi T, Welch C, Wang Q, et al.
J Clin Invest
. 2009 Mar;
119(4):1029-41.
PMID: 19273907
Type 2 diabetes is associated with accelerated atherogenesis, which may result from a combination of factors, including dyslipidemia characterized by increased VLDL secretion, and insulin resistance. To assess the hypothesis...
6.
Senokuchi T, Liang C, Seimon T, Han S, Matsumoto M, Banks A, et al.
Diabetes
. 2008 Aug;
57(11):2967-76.
PMID: 18728232
Objective: Endoplasmic reticulum stress increases macrophage apoptosis, contributing to the complications of atherosclerosis. Insulin-resistant macrophages are more susceptible to endoplasmic reticulum stress-associated apoptosis probably contributing to macrophage death and necrotic...
7.
Tabas I, Seimon T, Arellano J, Li Y, Forcheron F, Cui D, et al.
Novartis Found Symp
. 2008 Feb;
286:99-109.
PMID: 18269177
Macrophage death in advanced atherosclerosis causes plaque necrosis, which promotes plaque rupture and acute atherothrombotic vascular events. Of interest, plaque necrosis and atherothrombotic disease are markedly increased in diabetes and...
8.
Liang C, Han S, Senokuchi T, Tall A
Circ Res
. 2007 Jun;
100(11):1546-55.
PMID: 17556668
The macrophage has emerged as an important player in the pathogenesis of both atherosclerosis and insulin resistance. Cross-talk between inflammatory macrophages and adipocytes may be involved in insulin resistance in...
9.
Han S, Liang C, DeVries-Seimon T, Ranalletta M, Welch C, Collins-Fletcher K, et al.
Cell Metab
. 2006 Apr;
3(4):257-66.
PMID: 16581003
Insulin resistance in diabetes and metabolic syndrome is thought to increase susceptibility to atherosclerotic cardiovascular disease, but the underlying mechanisms are poorly understood. To evaluate the possibility that decreased insulin...
10.
Vikramadithyan R, Hu Y, Noh H, Liang C, Hallam K, Tall A, et al.
J Clin Invest
. 2005 Aug;
115(9):2434-43.
PMID: 16127462
Direct evidence that hyperglycemia, rather than concomitant increases in known risk factors, induces atherosclerosis is lacking. Most diabetic mice do not exhibit a higher degree of atherosclerosis unless the development...