Cheryl F Lichti
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Explore the profile of Cheryl F Lichti including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Srivastava N, Vomund A, Peterson O, Abousaway O, Li T, Kain L, et al.
bioRxiv
. 2024 Nov;
PMID: 39605669
Type 1 diabetes (T1D) affects a genetically susceptible population that develops autoreactive T cells attacking insulin-producing pancreatic β cells. Increasingly, neoantigens are recognized as critical drivers of this autoimmune response....
2.
Kim M, Gao W, Lichti C, Gu X, Dykstra T, Cao J, et al.
Nature
. 2024 Oct;
637(8044):176-183.
PMID: 39476864
Despite the presence of strategically positioned anatomical barriers designed to protect the central nervous system (CNS), it is not entirely isolated from the immune system. In fact, it remains physically...
3.
Hu H, Vomund A, Peterson O, Srivastava N, Li T, Kain L, et al.
Nat Commun
. 2024 Sep;
15(1):8318.
PMID: 39333495
Autoimmune attack toward pancreatic β cells causes permanent loss of glucose homeostasis in type 1 diabetes (T1D). Insulin secretory granules store and secrete insulin but are also thought to be...
4.
Gao W, Kim M, Dykstra T, Du S, Boskovic P, Lichti C, et al.
Nature
. 2024 Sep;
634(8034):693-701.
PMID: 39232158
Traumatic injuries to the central nervous system (CNS) afflict millions of individuals worldwide, yet an effective treatment remains elusive. Following such injuries, the site is populated by a multitude of...
5.
Nanaware P, Khan Z, Clement C, Shetty M, Mota I, Seltzer E, et al.
Cell Rep
. 2024 Jun;
43(6):114311.
PMID: 38848214
The lymphatic fluid is the conduit by which part of the tissue "omics" is transported to the draining lymph node for immunosurveillance. Following cannulation of the pre-nodal cervical and mesenteric...
6.
Meng W, Takeuchi Y, Ward J, Sultan H, Arthur C, Mardis E, et al.
Cancer Immunol Res
. 2024 May;
12(8):988-1006.
PMID: 38768391
Cancer neoantigens have been shown to elicit cancer-specific T-cell responses and have garnered much attention for their roles in both spontaneous and therapeutically induced antitumor responses. Mass spectrometry (MS) profiling...
7.
Srivastava N, Hu H, Peterson O, Vomund A, Stremska M, Zaman M, et al.
Immunity
. 2024 May;
57(7):1629-1647.e8.
PMID: 38754432
The pancreatic islet microenvironment is highly oxidative, rendering β cells vulnerable to autoinflammatory insults. Here, we examined the role of islet resident macrophages in the autoimmune attack that initiates type...
8.
Meng W, Schreiber R, Lichti C
Adv Immunol
. 2023 Dec;
160:1-36.
PMID: 38042584
The role of aberrantly expressed proteins in tumors in driving immune-mediated control of cancer has been well documented for more than five decades. Today, we know that both aberrantly expressed...
9.
Lichti C, Wan X
Semin Immunol
. 2023 Feb;
66:101730.
PMID: 36827760
In autoimmune diseases, recognition of self-antigens presented by major histocompatibility complex (MHC) molecules elicits unexpected attack of tissue by autoantibodies and/or autoreactive T cells. Post-translational modification (PTM) may alter the...
10.
Lichti C, Vigneron N, Clauser K, Van den Eynde B, Bassani-Sternberg M
Cancer Immunol Res
. 2022 Feb;
10(3):275-284.
PMID: 35105607
Within the tumor immunology community, the topic of proteasomal spliced peptides (PSP) has generated a great deal of controversy. In the earliest reports, careful biological validation led to the conclusion...