Cheryl Arrowsmith
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Explore the profile of Cheryl Arrowsmith including associated specialties, affiliations and a list of published articles.
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48
Citations
2108
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Recent Articles
11.
Saraon P, Snider J, Schormann W, Rai A, Radulovich N, Sanchez-Osuna M, et al.
J Mol Biol
. 2021 Oct;
433(23):167294.
PMID: 34662547
Activating mutations in the epidermal growth factor receptor (EGFR) are common driver mutations in non-small cell lung cancer (NSCLC). First, second and third generation EGFR tyrosine kinase inhibitors (TKIs) are...
12.
Gradl S, Steuber H, Weiske J, Szewczyk M, Schmees N, Siegel S, et al.
SLAS Discov
. 2021 Jun;
26(8):947-960.
PMID: 34154424
SMYD3 (SET and MYND domain-containing protein 3) is a protein lysine methyltransferase that was initially described as an H3K4 methyltransferase involved in transcriptional regulation. SMYD3 has been reported to methylate...
13.
Ostrop J, Zwiggelaar R, Pedersen M, Gerbe F, Bosl K, Lindholm H, et al.
Front Cell Dev Biol
. 2021 Feb;
8:618552.
PMID: 33575256
Intestinal organoids are an excellent model to study epithelial biology. Yet, the selection of analytical tools to accurately quantify heterogeneous organoid cultures remains limited. Here, we developed a semi-automated organoid...
14.
Conway S, Arimondo P, Arrowsmith C, Jin J, Luo C, Meanwell N, et al.
J Med Chem
. 2020 Oct;
63(21):12129-12130.
PMID: 33090784
No abstract available.
15.
Zwiggelaar R, Lindholm H, Fosslie M, Pedersen M, Ohta Y, Diez-Sanchez A, et al.
Sci Adv
. 2020 Sep;
6(37).
PMID: 32917713
Intestinal epithelial homeostasis is maintained by adult intestinal stem cells, which, alongside Paneth cells, appear after birth in the neonatal period. We aimed to identify regulators of neonatal intestinal epithelial...
16.
Fagan V, Johansson C, Gileadi C, Monteiro O, Dunford J, Nibhani R, et al.
J Med Chem
. 2019 Sep;
62(20):9008-9025.
PMID: 31550156
Modifications of histone tails, including lysine/arginine methylation, provide the basis of a "chromatin or histone code". Proteins that contain "reader" domains can bind to these modifications and form specific effector...
17.
Krug B, De Jay N, Harutyunyan A, Deshmukh S, Marchione D, Guilhamon P, et al.
Cancer Cell
. 2019 Sep;
36(3):338-339.
PMID: 31526762
No abstract available.
18.
Krug B, De Jay N, Harutyunyan A, Deshmukh S, Marchione D, Guilhamon P, et al.
Cancer Cell
. 2019 May;
35(5):782-797.e8.
PMID: 31085178
High-grade gliomas defined by histone 3 K27M driver mutations exhibit global loss of H3K27 trimethylation and reciprocal gain of H3K27 acetylation, respectively shaping repressive and active chromatin landscapes. We generated...
19.
Casey A, Sinha A, Singhania R, Livingstone J, Waterhouse P, Tharmapalan P, et al.
J Cell Biol
. 2018 Jun;
217(8):2951-2974.
PMID: 29921600
The mammary epithelium depends on specific lineages and their stem and progenitor function to accommodate hormone-triggered physiological demands in the adult female. Perturbations of these lineages underpin breast cancer risk,...
20.
Xu Z, Stogios P, Quaile A, Forsberg K, Patel S, Skarina T, et al.
ACS Infect Dis
. 2017 Aug;
3(9):653-665.
PMID: 28756664
Aminoglycoside N-acetyltransferases (AACs) confer resistance against the clinical use of aminoglycoside antibiotics. The origin of AACs can be traced to environmental microbial species representing a vast reservoir for new and...