Chen Varol
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Explore the profile of Chen Varol including associated specialties, affiliations and a list of published articles.
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47
Citations
3482
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Recent Articles
1.
Dsilva A, Wagner A, Itan M, Rhone N, Avlas S, Gordon Y, et al.
bioRxiv
. 2025 Mar;
PMID: 40060399
Rationale: Thymic stromal lymphopoietin (TSLP) and IL-33 are alarmins implicated in EoE pathogenesis by activating multiple cells including mast cells (MCs). Whether TSLP or IL-33 have a role in EoE...
2.
Hammoud R, Kaur K, Koehler J, Baggio L, Wong C, Advani K, et al.
JCI Insight
. 2024 Dec;
10(3).
PMID: 39723966
Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) are gut-derived peptide hormones that potentiate glucose-dependent insulin secretion. The clinical development of GIP receptor-GLP-1 receptor (GIPR-GLP-1R) multiagonists exemplified by tirzepatide...
3.
Hubel E, Neumann A, Fishman S, Schaffer O, Erez N, Shrkihe B, et al.
Am J Pathol
. 2024 Mar;
194(6):941-957.
PMID: 38493927
Cholestatic injuries are accompanied by ductular reaction, initiated by proliferation and activation of biliary epithelial cells (BECs), leading to fibrosis. Sortilin (encoded by Sort1) facilitates IL-6 secretion and leukemia inhibitory...
4.
Margalit Grigg L, Shrkihe B, Efimova I, Solodeev I, Shteingard Y, Shani N, et al.
Lab Invest
. 2023 Dec;
104(2):100308.
PMID: 38135154
Obesity predisposes to metabolic dysfunction-associated fatty liver disease (MAFLD), cardiovascular disease, and type 2 diabetes. Accumulating evidence suggests a complex role of NLR family pyrin domain containing 3 (NLRP3) inflammasome...
5.
Avlas S, Shani G, Rhone N, Itan M, Dolitzky A, Hazut I, et al.
Allergy
. 2022 Sep;
78(2):464-476.
PMID: 36070083
Background: Eosinophilic esophagitis (EoE) is a chronic, food-driven allergic disease, characterized by eosinophil-rich inflammation in the esophagus. The histopathological and clinical features of EoE have been attributed to overproduction of...
6.
Cohen K, Mouhadeb O, Shlomo S, Langer M, Neumann A, Erez N, et al.
Cell Rep
. 2021 Nov;
37(7):110026.
PMID: 34788631
Liver-resident macrophages Kupffer cells (KCs) and infiltrating Ly6C monocytes both contribute to liver tissue regeneration in various pathologies but also to disease progression upon disruption of orderly consecutive regeneration cascades....
7.
Efimova I, Steinberg I, Zvibel I, Neumann A, Mantelmacher D, Drucker D, et al.
Front Immunol
. 2021 Mar;
12:643144.
PMID: 33717200
Glucose-dependent insulinotropic polypeptide (GIP) communicates information on energy availability from the gut to peripheral tissues. Disruption of its signaling in myeloid immune cells during high-fat diet (HFD)-induced obesity impairs energy...
8.
Ginhoux F, Mildner A, Gautier E, Schlitzer A, Jakubzick C, Varol C, et al.
Front Immunol
. 2021 Jan;
11:626725.
PMID: 33488633
No abstract available.
9.
Shimshoni E, Adir I, Afik R, Solomonov I, Shenoy A, Adler M, et al.
Matrix Biol
. 2020 Nov;
96:47-68.
PMID: 33246101
Identification of early processes leading to complex tissue pathologies, such as inflammatory bowel diseases, poses a major scientific and clinical challenge that is imperative for improved diagnosis and treatment. Most...
10.
Zigmond E, Varol C
Immunity
. 2020 Sep;
53(3):479-481.
PMID: 32937148
Liver macrophages play critical roles in the pathogenesis of non-alcoholic steatohepatitis (NASH). In this issue of Immunity, Tran et al. and Remmerie et al. reveal that Ly6C monocytes in NASH...