Charlotte H Dean
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Explore the profile of Charlotte H Dean including associated specialties, affiliations and a list of published articles.
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39
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728
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Recent Articles
1.
Lehmann M, Krishnan R, Sucre J, Kulkarni H, Pineda R, Anderson C, et al.
Am J Respir Cell Mol Biol
. 2024 Nov;
PMID: 39499861
The urgent need for effective treatments for acute and chronic lung diseases underscores the significance of developing innovative preclinical human research tools. The 2023 ATS Workshop on Precision Cut Lung...
2.
Cheong S, Luis T, Hind M, Dean C
Bio Protoc
. 2024 Apr;
14(8):e4980.
PMID: 38686349
Precision-cut lung slices (PCLS), ex vivo 3D lung tissue models, have been widely used for various applications in lung research. PCLS serve as an excellent intermediary between in vitro and...
3.
Kim S, McTeague D, Cheong S, Hind M, Dean C
Front Cell Dev Biol
. 2024 Mar;
12:1349312.
PMID: 38476262
Many adult lung diseases involve dysregulated lung repair. Deciphering the molecular and cellular mechanisms that govern intrinsic lung repair is essential to develop new treatments to repair/regenerate the lungs. Aberrant...
4.
Burgess J, Weiss D, Westergren-Thorsson G, Wigen J, Dean C, Mumby S, et al.
Am J Respir Cell Mol Biol
. 2024 Jan;
70(4):239-246.
PMID: 38190723
The extracellular matrix (ECM) is not just a three-dimensional scaffold that provides stable support for all cells in the lungs, but also an important component of chronic fibrotic airway, vascular,...
5.
Cheong S, Luis T, Stewart M, Hillier R, Hind M, Dean C
Dis Model Mech
. 2023 Oct;
16(11).
PMID: 37828896
Precision-cut lung slices (PCLS) are used for a variety of applications. However, methods to manipulate genes in PCLS are currently limited. We developed a new method, TAT-Cre recombinase-mediated floxed allele...
6.
Dean C, Cheong S
Adv Exp Med Biol
. 2023 May;
1413:17-28.
PMID: 37195524
Models are essential to further our understanding of lung development and regeneration and to facilitate identification and testing of potential treatments for lung diseases. A wide variety of rodent and...
7.
Papakrivopoulou E, Jafree D, Dean C, Long D
Front Physiol
. 2021 Mar;
12:599529.
PMID: 33716764
The orientation of cells in two-dimensional and three-dimensional space underpins how the kidney develops and responds to disease. The process by which cells orientate themselves within the plane of a...
8.
Akram K, Yates L, Mongey R, Rothery S, Gaboriau D, Sanderson J, et al.
Bio Protoc
. 2021 Mar;
9(20):e3403.
PMID: 33654904
Alveoli are the gas-exchange units of lung. The process of alveolar development, alveologenesis, is regulated by a complex network of signaling pathways that act on various cell types including alveolar...
9.
Kim S, Mongey R, Griffiths M, Hind M, Dean C
Curr Protoc Mouse Biol
. 2020 Nov;
10(4):e85.
PMID: 33217226
Recent advances in cell culture models like air-liquid interface culture and ex vivo models such as organoids have advanced studies of lung biology; however, gaps exist between these models and...
10.
Cheong S, Akram K, Matellan C, Kim S, Gaboriau D, Hind M, et al.
Front Cell Dev Biol
. 2020 Nov;
8:577201.
PMID: 33195213
VANGL2 is a component of the planar cell polarity (PCP) pathway, which regulates tissue polarity and patterning. The mutation causes lung branching defects due to dysfunctional actomyosin-driven morphogenesis. Since the...