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Charles V Rice

Explore the profile of Charles V Rice including associated specialties, affiliations and a list of published articles. Areas
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Articles 35
Citations 298
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Recent Articles
1.
Best W, Ferrell M, Boris A, Heydarian N, Panlilio H, Rice C
ChemMedChem . 2024 May; 19(17):e202300689. PMID: 38806411
PEGylated branched polyethylenimine (PEG-BPEI) has antibacterial and antibiofilm properties. Exposure to PEG-BPEI through serial passage leads to resistant P. aeruginosa strains. The minimum inhibitory concentration (MIC) of 600 Da BPEI...
2.
Heydarian N, Ferrell M, Nair A, Roedl C, Peng Z, Nguyen T, et al.
ChemMedChem . 2024 May; 19(15):e202400011. PMID: 38740551
The innate immune system is an evolutionarily conserved pathogen recognition mechanism that serves as the first line of defense against tissue damage or pathogen invasion. Unlike the adaptive immunity that...
3.
Heydarian N, Ferrell M, Nair A, Roedl C, Peng Z, Nguyen T, et al.
ACS Omega . 2024 Mar; 9(9):10967-10978. PMID: 38463252
Innate immunity has considerable specificity and can discriminate between individual species of microbes. In this regard, pathogens are "seen" as dangerous to the host and elicit an inflammatory response capable...
4.
Wouters C, Heydarian N, Pusavat J, Panlilio H, Lam A, Moen E, et al.
Biochim Biophys Acta Biomembr . 2023 May; 1865(6):184172. PMID: 37201561
Bacterial infections caused by Gram-negative pathogens, such as those in the family Enterobacteriaceae, are among the most difficult to treat because effective therapeutic options are either very limited or non-existent....
5.
Heydarian N, Wouters C, Neel A, Ferrell M, Panlilio H, Haight T, et al.
ChemMedChem . 2022 Dec; 18(3):e202200428. PMID: 36542457
Carbapenem-resistant Enterobacteriaceae (CRE) are emerging pathogens that cause variety of severe infections. CRE evade antibiotic treatments because these bacteria produce enzymes that degrade a wide range of antibiotics including carbapenems...
6.
Panlilio H, Neel A, Heydarian N, Best W, Atkins I, Boris A, et al.
ACS Omega . 2022 Dec; 7(49):44825-44835. PMID: 36530285
Biofilm formation is an adaptive resistance mechanism that pathogens employ to survive in the presence of antimicrobials. is an infectious Gram-negative bacterium whose biofilm allows it to withstand antimicrobial attack...
7.
Moen E, Lam A, Pusavat J, Wouters C, Panlilio H, Heydarian N, et al.
Chem Biol Drug Des . 2021 Dec; 101(3):489-499. PMID: 34923750
Antibiotic resistance is a growing concern in the medical field. Drug-susceptible infections are often treated with β-lactam antibiotics, which bind to enzymes known as penicillin-binding proteins (PBPs). When the PBPs...
8.
Panlilio H, Lam A, Heydarian N, Haight T, Wouters C, Moen E, et al.
ACS Infect Dis . 2021 May; 7(6):1657-1665. PMID: 33945257
The rise of life-threatening carbapenem-resistant (CRE) infections has become a critical medical threat. Some of the most dangerous CRE bacteria can produce enzymes that degrade a wide range of antibiotics,...
9.
Panlilio H, Rice C
Biotechnol Bioeng . 2021 Mar; 118(6):2129-2141. PMID: 33748946
Advances in biotechnology to treat and cure human disease have markedly improved human health and the development of modern societies. However, substantial challenges remain to overcome innate biological factors that...
10.
Lam A, Moen E, Pusavat J, Wouters C, Panlilio H, Ferrell M, et al.
ACS Omega . 2020 Oct; 5(40):26262-26270. PMID: 33073153
Bacterial biofilms, often impenetrable to antibiotic medications, are a leading cause of poor wound healing. The prognosis is worse for wounds with biofilms of antimicrobial-resistant (AMR) bacteria, such as methicillin-resistant...