Anh K Lam
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Explore the profile of Anh K Lam including associated specialties, affiliations and a list of published articles.
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22
Citations
156
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Recent Articles
1.
B cell focused transient immune suppression protocol for efficient AAV readministration to the liver
Rana J, Herzog R, Munoz-Melero M, Yamada K, Kumar S, Lam A, et al.
Mol Ther Methods Clin Dev
. 2024 Mar;
32(1):101216.
PMID: 38440160
Adeno-associated virus (AAV) vectors are used for correcting multiple genetic disorders. Although the goal is to achieve lifelong correction with a single vector administration, the ability to redose would enable...
2.
Zhang J, Frabutt D, Chrzanowski M, Li N, Miller L, Tian J, et al.
Mol Ther Methods Clin Dev
. 2024 Feb;
32(1):101206.
PMID: 38390555
Self-complementary AAV vectors (scAAV) use a mutant inverted terminal repeat (mITR) for efficient packaging of complementary stranded DNA, enabling rapid transgene expression. However, inefficient resolution at the mITR leads to...
3.
Lam A, Mulcrone P, Frabutt D, Zhang J, Chrzanowski M, Arisa S, et al.
Adv Cell Gene Ther
. 2023 Dec;
2023.
PMID: 38130431
Recombinant adeno-associated viruses (AAVs) have emerged as a widely used gene delivery platform for both basic research and human gene therapy. To ensure and improve the safety profile of AAV...
4.
Kumar S, Biswas M, Cao D, Arisa S, Munoz-Melero M, Lam A, et al.
Mol Ther
. 2023 Dec;
32(2):325-339.
PMID: 38053332
Upon viral infection of the liver, CD8 T cell responses may be triggered despite the immune suppressive properties that manifest in this organ. We sought to identify pathways that activate...
5.
Syed F, Krishnan P, Chang G, Langlais S, Hati S, Yamada K, et al.
bioRxiv
. 2023 Jul;
PMID: 37398133
MicroRNAs (miRNAs) are small non-coding RNAs that play a crucial role in modulating gene expression and are enriched in cell-derived extracellular vesicles (EVs). We investigated whether miRNAs from human islets...
6.
Mulcrone P, Lam A, Frabutt D, Zhang J, Chrzanowski M, Herzog R, et al.
Sci Rep
. 2023 May;
13(1):8436.
PMID: 37231038
Although more adeno-associated virus AAV-based drugs enter the clinic, vector tissue tropism remains an unresolved challenge that limits its full potential despite that the tissue tropism of naturally occurring AAV...
7.
Wouters C, Heydarian N, Pusavat J, Panlilio H, Lam A, Moen E, et al.
Biochim Biophys Acta Biomembr
. 2023 May;
1865(6):184172.
PMID: 37201561
Bacterial infections caused by Gram-negative pathogens, such as those in the family Enterobacteriaceae, are among the most difficult to treat because effective therapeutic options are either very limited or non-existent....
8.
Zhang J, Chrzanowski M, Frabutt D, Lam A, Mulcrone P, Li L, et al.
J Med Virol
. 2022 Dec;
95(1):e28433.
PMID: 36571262
Recombinant adeno-associated virus (rAAV) vectors carry a cassette of interest retaining only the inverted terminal repeats (ITRs) from the wild-type virus. Conventional rAAV production primarily uses a vector plasmid as...
9.
Mulcrone P, Zhang J, Pride P, Lam A, Frabutt D, Ball-Kell S, et al.
Adv Cell Gene Ther
. 2022 Dec;
2022.
PMID: 36507314
Recombinant AAV (rAAV) gene therapy is being investigated as an effective therapy for several diseases including hemophilia B. Reports of liver tumor development in certain mouse models due to AAV...
10.
Lam A, Zhang J, Frabutt D, Mulcrone P, Li L, Zeng L, et al.
Mol Ther Methods Clin Dev
. 2022 Oct;
27:185-194.
PMID: 36284765
Adeno-associated virus (AAV) has emerged as a leading platform for gene therapy. With the skyrocketing rate of AAV research and the prevalence of many new engineered capsids being investigated in...