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Chaoqun Chen

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Articles 86
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Recent Articles
11.
Ding T, Fu S, Zhang X, Yang F, Zhang J, Xu H, et al.
Genomics Proteomics Bioinformatics . 2024 Oct; 22(3). PMID: 39394698
Topologically associating domain (TAD) reorganization commonly occurs in the cell nucleus and contributes to gene activation and inhibition through the separation or fusion of adjacent TADs. However, functional genes impacted...
12.
Ding T, Xu H, Zhang X, Yang F, Zhang J, Shi Y, et al.
Nat Commun . 2024 Sep; 15(1):8385. PMID: 39333493
The spatial co-presence of aberrant long non-coding RNAs (lncRNAs) and abnormal coding genes contributes to malignancy development in various tumors. However, precise coordinated mechanisms underlying this phenomenon in tumorigenesis remains...
13.
Chen C, Lai H, Song P, Gu X
J Mech Behav Biomed Mater . 2024 Sep; 160:106750. PMID: 39293136
Proanthocyanidin (PA) has demonstrated promise as a dental biomodifier for maintaining dentin collagen integrity, yet there is limited evidence regarding its efficacy in dentin repair. The aim of this study...
14.
Wang S, Li Z, Chen C, Guo T, Zhao S, Zhao J, et al.
J Cell Physiol . 2024 Sep; 239(12):e31426. PMID: 39221900
Dysregulation of alternative pre-mRNA splicing plays a critical role in the progression of cancers, yet the underlying molecular mechanisms remain largely unknown. It is reported that metastasis-associated in colon cancer...
15.
Zhi L, Chen C, Zhang G, Huang T, He W, Zhang J, et al.
Sci China Life Sci . 2024 Aug; 67(10):2186-2197. PMID: 39110401
Increasing evidence suggests that deregulated RNA splicing factors play critical roles in tumorigenesis; however, their specific involvement in colon cancer remains largely unknown. Here we report that the splicing factor...
16.
Xiao W, Chen C, Xia S, Li Z, Ding T, Zhou J, et al.
J Virol . 2024 Jul; 98(8):e0088024. PMID: 39078176
Importance: The identification of viral receptors is of great significance, potentially extending our understanding of viral infection and pathogenesis. Porcine deltacoronavirus (PDCoV) is an emerging enteropathogenic coronavirus with the potential...
17.
Huang F, Dai Z, Yu J, Wang K, Chen C, Chen D, et al.
Elife . 2024 Jul; 13. PMID: 38995840
Aberrant alternative splicing is well-known to be closely associated with tumorigenesis of various cancers. However, the intricate mechanisms underlying breast cancer metastasis driven by deregulated splicing events remain largely unexplored....
18.
Lv Y, Sun S, Zhang J, Wang C, Chen C, Zhang Q, et al.
Cancer Lett . 2024 May; 596:216988. PMID: 38797234
Type I interferons exhibit anti-proliferative and anti-cancer activities, but their detailed regulatory mechanisms in cancer have not been fully elucidated yet. RNA binding proteins are master orchestrators of gene regulation,...
19.
Zhang X, Ding T, Yang F, Xu H, Zhang J, Bai Y, et al.
Cell Death Discov . 2024 May; 10(1):249. PMID: 38782895
Multiple gene abnormalities are major drivers of tumorigenesis. NF-κB p65 overactivation and cGAS silencing are important triggers and genetic defects that accelerate tumorigenesis. However, the simultaneous correction of NF-κB p65...
20.
Wang W, Gao R, Yang D, Ma M, Zang R, Wang X, et al.
Genes Dev . 2024 Mar; 38(3-4):168-188. PMID: 38479840
CTCF is crucial for chromatin structure and transcription regulation in early embryonic development. However, the kinetics of CTCF chromatin occupation in preimplantation embryos have remained unclear. In this study, we...