Chani Stossel
Overview
Explore the profile of Chani Stossel including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
353
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0
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Recent Articles
1.
Shimoni-Sebag A, Abramovich I, Agranovich B, Massri R, Stossel C, Atias D, et al.
Radiother Oncol
. 2024 Nov;
202:110606.
PMID: 39521275
Purpose: Pancreatic ductal adenocarcinoma (PDAC) is remarkably resistant to standard modalities, including radiotherapy. We hypothesized that metabolic reprogramming may underlie PDAC radioresistance, and moreover, that it would be possible to...
2.
Zerbib J, Ippolito M, Eliezer Y, De Feudis G, Reuveni E, Savir Kadmon A, et al.
Nat Commun
. 2024 Sep;
15(1):7772.
PMID: 39251587
Aneuploidy is a hallmark of human cancer, yet the molecular mechanisms to cope with aneuploidy-induced cellular stresses remain largely unknown. Here, we induce chromosome mis-segregation in non-transformed RPE1-hTERT cells and...
3.
Hoang D, Dinstag G, Shulman E, Hermida L, Ben-Zvi D, Elis E, et al.
Nat Cancer
. 2024 Jul;
5(9):1305-1317.
PMID: 38961276
Advances in artificial intelligence have paved the way for leveraging hematoxylin and eosin-stained tumor slides for precision oncology. We present ENLIGHT-DeepPT, an indirect two-step approach consisting of (1) DeepPT, a...
4.
Golan S, Bar V, Salpeter S, Neev G, Creiderman G, Kedar D, et al.
Front Med (Lausanne)
. 2023 Oct;
10:1221484.
PMID: 37840996
Introduction: organ cultures (EVOC) were recently optimized to sustain cancer tissue for 5 days with its complete microenvironment. We examined the ability of an EVOC platform to predict patient response...
5.
Hoang D, Dinstag G, Hermida L, Ben-Zvi D, Elis E, Caley K, et al.
Res Sq
. 2023 Oct;
PMID: 37790315
Advances in artificial intelligence have paved the way for leveraging hematoxylin and eosin (H&E)-stained tumor slides for precision oncology. We present ENLIGHT-DeepPT, an approach for predicting response to multiple targeted...
6.
Stossel C, Raitses-Gurevich M, Atias D, Beller T, Glick Gorman Y, Halperin S, et al.
Cancer Discov
. 2023 Jul;
13(8):1826-1843.
PMID: 37449843
Significance: glBRCA PDAC has a favorable response to platinum/PARP inhibition. However, most patients develop resistance. Additional treatment options for this unique subpopulation are needed. We generated model systems in PDXs...
7.
Gavish A, Tyler M, Greenwald A, Hoefflin R, Simkin D, Tschernichovsky R, et al.
Nature
. 2023 May;
618(7965):598-606.
PMID: 37258682
Each tumour contains diverse cellular states that underlie intratumour heterogeneity (ITH), a central challenge of cancer therapeutics. Dozens of recent studies have begun to describe ITH by single-cell RNA sequencing,...
8.
Goldman O, Adler L, Hajaj E, Croese T, Darzi N, Galai S, et al.
Cancer Discov
. 2023 Mar;
13(7):1616-1635.
PMID: 36972357
Significance: Cancer growth requires a permanent nutrient supply starting from early disease stages. We find that the tumor extends its effect to the host's liver to obtain nutrients and rewires...
9.
Jbara A, Lin K, Stossel C, Siegfried Z, Shqerat H, Amar-Schwartz A, et al.
Nature
. 2023 Mar;
617(7959):147-153.
PMID: 36949200
Pancreatic ductal adenocarcinoma (PDA) is characterized by aggressive local invasion and metastatic spread, leading to high lethality. Although driver gene mutations during PDA progression are conserved, no specific mutation is...
10.
Golan T, Atias D, Stossel C, Raitses-Gurevich M
Adv Drug Deliv Rev
. 2021 Feb;
171:257-265.
PMID: 33617901
Pancreatic ductal adenocarcinoma (PDAC) is a dismal disease. The majority of patients diagnosed at an advanced, metastatic stage, and poor overall survival rates. The most clinically meaningful subtype obtained from...