Early Infiltration of Innate Immune Cells to the Liver Depletes HNF4α and Promotes Extrahepatic Carcinogenesis

Overview

Journal Cancer Discov

Specialty Oncology

Date 2023 Mar 27

PMID 36972357

Authors

Omer Goldman

Lital N Adler

Emma Hajaj

Tommaso Croese

Naama Darzi

Sivan Galai

Hila Tishler

Yarden Ariav

Dor Lavie

Liat Fellus-Alyagor

Roni Oren

Yuri Kuznetsov

Eyal David

Rami Jaschek

Chani Stossel

Oded Singer

Sergey Malitsky

Renana Barak

Rony Seger

Neta Erez

Ido Amit

Amos Tanay

Ann Saada

Talia Golan

Tamar Rubinek

Joo Sang Lee

Shay Ben-Shachar

Ido Wolf

Ayelet Erez

Affiliations

Soon will be listed here.

Abstract

Significance: Cancer growth requires a permanent nutrient supply starting from early disease stages. We find that the tumor extends its effect to the host's liver to obtain nutrients and rewires the systemic and tissue-specific metabolism early during carcinogenesis. Preserving liver metabolism restricts tumor growth and improves cancer outcomes. This article is highlighted in the In This Issue feature, p. 1501.

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