Chander S Digwal
Overview
Explore the profile of Chander S Digwal including associated specialties, affiliations and a list of published articles.
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14
Citations
130
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Recent Articles
1.
Bay S, Rodina A, Haut F, Roychowdhury T, Argyrousi E, Staniszewski A, et al.
Res Sq
. 2025 Feb;
PMID: 39989971
Alzheimer's disease (AD) progresses as a continuum, from preclinical stages to late-stage cognitive decline, yet the molecular mechanisms driving this progression remain poorly understood. Here, we provide a systems-level map...
2.
Roychowdhury T, McNutt S, Pasala C, Nguyen H, Thornton D, Sharma S, et al.
Nat Commun
. 2024 Oct;
15(1):8912.
PMID: 39414766
The intricate network of protein-chaperone interactions is crucial for maintaining cellular function. Recent discoveries have unveiled the existence of specialized chaperone assemblies, known as epichaperomes, which serve as scaffolding platforms...
3.
Magni A, Sciva C, Castelli M, Digwal C, Rodina A, Sharma S, et al.
Chemistry
. 2024 Jul;
30(54):e202401957.
PMID: 39042517
Post-translational modifications such as protein N-glycosylation, significantly influence cellular processes. Dysregulated N-glycosylation, exemplified in Grp94, a member of the Hsp90 family, leads to structural changes and the formation of epichaperomes,...
4.
Bay S, Digwal C, Rodilla Martin A, Sharma S, Stanisavljevic A, Rodina A, et al.
Biomedicines
. 2024 Jun;
12(6).
PMID: 38927459
Neurodegenerative disorders, including Alzheimer's disease (AD) and Parkinson's disease (PD), represent debilitating conditions with complex, poorly understood pathologies. Epichaperomes, pathologic protein assemblies nucleated on key chaperones, have emerged as critical...
5.
McNutt S, Roychowdhury T, Pasala C, Nguyen H, Thornton D, Sharma S, et al.
Res Sq
. 2024 Apr;
PMID: 38645031
The intricate protein-chaperone network is vital for cellular function. Recent discoveries have unveiled the existence of specialized chaperone complexes called epichaperomes, protein assemblies orchestrating the reconfiguration of protein-protein interaction networks,...
6.
Sharma S, Joshi S, Kalidindi T, Digwal C, Panchal P, Lee S, et al.
Biomedicines
. 2023 Oct;
11(10).
PMID: 37892973
Drugs with a long residence time at their target sites are often more efficacious in disease treatment. The mechanism, however, behind prolonged retention at the site of action is often...
7.
Chiosis G, Digwal C, Trepel J, Neckers L
Nat Rev Mol Cell Biol
. 2023 Jul;
24(11):797-815.
PMID: 37524848
Heat shock protein 90 (HSP90) is a chaperone with vital roles in regulating proteostasis, long recognized for its function in protein folding and maturation. A view is emerging that identifies...
8.
Rodina A, Xu C, Digwal C, Joshi S, Patel Y, Santhaseela A, et al.
Nat Commun
. 2023 Jun;
14(1):3742.
PMID: 37353488
Systems-level assessments of protein-protein interaction (PPI) network dysfunctions are currently out-of-reach because approaches enabling proteome-wide identification, analysis, and modulation of context-specific PPI changes in native (unengineered) cells and tissues are...
9.
Castelli M, Yan P, Rodina A, Digwal C, Panchal P, Chiosis G, et al.
Structure
. 2023 Jun;
31(8):987-1004.e8.
PMID: 37343552
Protein-assembly defects due to an enrichment of aberrant conformational protein variants are emerging as a new frontier in therapeutics design. Understanding the structural elements that rewire the conformational dynamics of...
10.
Aaghaz S, Digwal C, Neshat N, Maurya I, Kumar V, Tikoo K, et al.
Bioorg Chem
. 2023 Apr;
136:106538.
PMID: 37079988
In spite of several attempts to develop newer pharmacophores as potential antimicrobial agents, the benzimidazole scaffold is still considered as one of the most sought after structural component towards the...