Chad Hadden
Overview
Explore the profile of Chad Hadden including associated specialties, affiliations and a list of published articles.
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Articles
4
Citations
18
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0
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Recent Articles
1.
Yi P, Rehmel J, Cassidy K, Hadden C, Campanale K, Patel N, et al.
Drug Metab Dispos
. 2012 Sep;
40(12):2354-64.
PMID: 22961682
The disposition and metabolism of isopropyl N-[(2S)-7-cyano-4-(2-pyridylmethyl)-2,3-dihydro-1H-cyclopenta[b]indol-2-yl]carbamate (LY2452473; a selective androgen receptor modulator) in humans was characterized after a single 15-mg (100 μCi) oral dose of [¹⁴C]LY2452473 to six healthy...
2.
He M, Ji T, Barbuch R, Campanale K, Lantz R, Hadden C, et al.
Xenobiotica
. 2011 Sep;
41(12):1108-21.
PMID: 21892880
LY377604 has a potential to form 4-hydroxycarbazole, which was reported in the literature as a mutagen. This safety concern led to our investigation of the metabolism and carcinogenicity of LY377604....
3.
Yi P, Hadden C, Kulanthaivel P, Calvert N, Annes W, Brown T, et al.
Drug Metab Dispos
. 2010 Jan;
38(4):554-65.
PMID: 20075192
Semagacestat is a functional gamma-secretase inhibitor that has been shown to reduce the rate of formation of amyloid-beta in vitro and in vivo. This study was conducted to characterize the...
4.
Hashizume T, Xu Y, Mohutsky M, Alberts J, Hadden C, Kalhorn T, et al.
Biochem Pharmacol
. 2008 Jan;
75(5):1240-50.
PMID: 18177842
The biological effects of 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) are terminated primarily by P450-dependent hydroxylation reactions. However, the hormone is also conjugated in the liver and a metabolite, presumably a glucuronide, undergoes...