Catherine Lee May
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Explore the profile of Catherine Lee May including associated specialties, affiliations and a list of published articles.
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21
Citations
614
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Recent Articles
1.
Bahl V, Rifkind R, Waite E, Hamdan Z, May C, Manduchi E, et al.
Sci Transl Med
. 2025 Jan;
17(779):eadi6148.
PMID: 39742505
Elevated glucagon concentrations have been reported in patients with type 2 diabetes (T2D). A critical role for α cell-intrinsic mechanisms in regulating glucagon secretion was previously established through genetic manipulation...
2.
Waite E, Tigue M, Yu M, Lahori D, Kelly K, May C, et al.
Diabetes
. 2024 Nov;
74(3):332-342.
PMID: 39571094
Article Highlights: Current mouse models for assessing islet function in vivo are limited due to unstable and variable hyperglycemia and/or high morbidity. We derived the IsletTester mouse to address these...
3.
Smoom R, May C, Lichtental D, Skordalakes E, Kaestner K, Tzfati Y
bioRxiv
. 2024 Mar;
PMID: 38464183
RTEL1 is an essential DNA helicase that plays multiple roles in genome stability and telomere length regulation. A variant of RTEL1 with a lysine at position 492 is associated with...
4.
Telomouse-a mouse model with human-length telomeres generated by a single amino acid change in RTEL1
Smoom R, May C, Ortiz V, Tigue M, Kolev H, Rowe M, et al.
Nat Commun
. 2023 Oct;
14(1):6708.
PMID: 37872177
Telomeres, the ends of eukaryotic chromosomes, protect genome integrity and enable cell proliferation. Maintaining optimal telomere length in the germline and throughout life limits the risk of cancer and enables...
5.
Bahl V, May C, Perez A, Glaser B, Kaestner K
Mol Metab
. 2021 Feb;
49:101193.
PMID: 33610858
Objective: While the molecular events controlling insulin secretion from β-cells have been documented in detail, the exact mechanisms governing glucagon release by α-cells are understood only partially. This is a...
6.
Ediger B, Lim H, Juliana C, Groff D, Williams L, Dominguez G, et al.
J Clin Invest
. 2016 Dec;
127(1):215-229.
PMID: 27941246
The recognition of β cell dedifferentiation in type 2 diabetes raises the translational relevance of mechanisms that direct and maintain β cell identity. LIM domain-binding protein 1 (LDB1) nucleates multimeric...
7.
Terry N, Walp E, Lee R, Kaestner K, May C
Am J Physiol Gastrointest Liver Physiol
. 2014 Sep;
307(10):G979-91.
PMID: 25214396
Enteroendocrine cells secrete over a dozen different hormones responsible for coordinating digestion, absorption, metabolism, and gut motility. Loss of enteroendocrine cells is a known cause of severe congenital diarrhea. Furthermore,...
8.
Terry N, Lee R, Walp E, Kaestner K, May C
J Pediatr Gastroenterol Nutr
. 2014 Aug;
60(2):192-9.
PMID: 25171319
Objectives: Severe congenital diarrhea occurs in approximately half of patients with Aristaless-Related Homeobox (ARX) null mutations. The cause of this diarrhea is unknown. In a mouse model of intestinal Arx...
9.
Wilcox C, Terry N, May C
PLoS One
. 2013 Nov;
8(11):e78741.
PMID: 24236044
ARX/Arx is a homeodomain-containing transcription factor necessary for the specification and early maintenance of pancreatic endocrine α-cells. Many transcription factors important to pancreas development, including ARX/Arx, are also crucial for...
10.
Wilcox C, Terry N, Walp E, Lee R, May C
PLoS One
. 2013 Jun;
8(6):e66214.
PMID: 23785486
The specification and differentiation of pancreatic endocrine cell populations (α-, β-, δ, PP- and ε-cells) is orchestrated by a combination of transcriptional regulators. In the pancreas, Aristaless-related homeobox gene (Arx)...