Catherine F Hughes
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Explore the profile of Catherine F Hughes including associated specialties, affiliations and a list of published articles.
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33
Citations
504
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Recent Articles
11.
Porter K, Hoey L, Hughes C, Ward M, Clements M, Strain J, et al.
Am J Clin Nutr
. 2021 Jun;
114(4):1286-1294.
PMID: 34134144
Background: Atrophic gastritis (AG) and use of proton pump inhibitors (PPIs) result in gastric acid suppression that can impair the absorption of vitamin B-12 from foods. The crystalline vitamin B-12...
12.
Ward M, Hughes C, Strain J, Reilly R, Cunningham C, Molloy A, et al.
BMC Med
. 2020 Nov;
18(1):318.
PMID: 33172445
Background: Genome-wide and clinical studies have linked the 677C→T polymorphism in the gene encoding methylenetetrahydrofolate reductase (MTHFR) with hypertension, whilst limited evidence shows that intervention with riboflavin (i.e. the MTHFR...
13.
Rankin D, Black M, Flanagan B, Hughes C, Moore A, Hoey L, et al.
JMIR Med Inform
. 2020 Sep;
8(9):e20995.
PMID: 32936084
Background: Machine learning techniques, specifically classification algorithms, may be effective to help understand key health, nutritional, and environmental factors associated with cognitive function in aging populations. Objective: This study aims...
14.
Jungert A, McNulty H, Hoey L, Ward M, Strain J, Hughes C, et al.
J Nutr
. 2020 Aug;
150(10):2699-2706.
PMID: 32805038
Background: Riboflavin is required to generate the active form of vitamin B-6 (pyridoxal 5'-phosphate; PLP) in tissues, but the relevance of this metabolic interaction for nutritional status of vitamin B-6...
15.
Amenyah S, Ward M, Strain J, McNulty H, Hughes C, Dollin C, et al.
Curr Dev Nutr
. 2020 Jul;
4(7):nzaa097.
PMID: 32666030
Recent advances in epigenetic research have enabled the development of epigenetic clocks, which have greatly enhanced our ability to investigate molecular processes that contribute to aging and age-related disease. These...
16.
Amenyah S, McMahon A, Ward M, Deane J, McNulty H, Hughes C, et al.
Biochimie
. 2020 Apr;
173:17-26.
PMID: 32334045
DNA methylation is important in regulating gene expression and genomic stability while aberrant DNA methylation is associated with disease. Riboflavin (FAD) is a cofactor for methylenetetrahydrofolate reductase (MTHFR), a critical...
17.
Rooney M, Bottiglieri T, Wasek-Patterson B, McMahon A, Hughes C, McCann A, et al.
Biochimie
. 2020 Apr;
173:91-99.
PMID: 32330571
Homozygosity for the C677T polymorphism in MTHFR (TT genotype) is associated with a 24-87% increased risk of hypertension. Blood pressure (BP) lowering was previously reported in adults with the TT...
18.
Amenyah S, Hughes C, Ward M, Rosborough S, Deane J, Thursby S, et al.
Nutr Rev
. 2020 Jan;
78(8):647-666.
PMID: 31977026
Context: Aberrant DNA methylation is linked to various diseases. The supply of methyl groups for methylation reactions is mediated by S-adenosylmethionine, which depends on the availability of folate and related...
19.
McNulty H, Strain J, Hughes C, Pentieva K, Ward M
Curr Dev Nutr
. 2020 Jan;
4(1):nzz102.
PMID: 31956853
Hypertension in adulthood is recognized as the leading risk factor contributing to mortality worldwide, primarily from cardiovascular disease, whereas hypertension in pregnancy leads to serious adverse fetal and maternal outcomes....
20.
McNulty H, Ward M, Hoey L, Hughes C, Pentieva K
Proc Nutr Soc
. 2019 Jun;
78(3):449-462.
PMID: 31155015
The functional effects of folate within C1 metabolism involve interrelationships with vitamin B12, vitamin B6 and riboflavin, and related gene-nutrient interactions. These B vitamins have important roles throughout life, from...