Catherine C Y Chang
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Explore the profile of Catherine C Y Chang including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Duong M, Nasrallah I, Wolk D, Chang C, Chang T
Front Aging Neurosci
. 2021 Apr;
13:647990.
PMID: 33841127
Vascular contributions to cognitive impairment and dementia (VCID) are a common cause of cognitive decline, yet limited therapies exist. This cerebrovascular disease results in neurodegeneration acute, chronic, local, and systemic...
12.
Song B, Wang C, Yao X, Yang L, Zhang W, Wang Z, et al.
Biochem J
. 2020 Dec;
477(24):4811.
PMID: 33367592
No abstract available.
13.
Neumann B, Chao K, Chang C, Chang T
Arch Biochem Biophys
. 2020 Aug;
691:108518.
PMID: 32735863
To conduct biochemical studies in vitro, membrane proteins (MPs) must be solubilized with detergents. While detergents are great tools, they can also inhibit the biological activity and/or perturb oligomerization of...
14.
Guan C, Niu Y, Chen S, Kang Y, Wu J, Nishi K, et al.
Nat Commun
. 2020 May;
11(1):2478.
PMID: 32424158
Sterol O-acyltransferase 1 (SOAT1) is an endoplasmic reticulum (ER) resident, multi-transmembrane enzyme that belongs to the membrane-bound O-acyltransferase (MBOAT) family. It catalyzes the esterification of cholesterol to generate cholesteryl esters...
15.
A simple method to disrupt and restore subunit interaction of acyl-CoA:cholesterol acyltransferase 1
Neumann B, Chang C, Chang T
MethodsX
. 2019 Nov;
6:2242-2247.
PMID: 31667125
Acyl-CoA:cholestereol acyltransferase 1 (ACAT1) is a two-fold dimer (homotetramer) and has two distinct dimerization domains. One domain is in an alpha-helical rich region near the cytoplasmic N-terminus. The other is...
16.
Melton E, Li H, Benson J, Sohn P, Huang L, Song B, et al.
J Biol Chem
. 2019 Sep;
294(43):15836-15849.
PMID: 31495784
Cholesterol esters are a key ingredient of foamy cells in atherosclerotic lesions; their formation is catalyzed by two enzymes: acyl-CoA:cholesterol acyltransferases (ACATs; also called sterol acyltransferases, or SOATs) ACAT1 and...
17.
Neumann B, Chang C, Chang T
Arch Biochem Biophys
. 2019 Jun;
671:103-110.
PMID: 31251920
Cholesterol is an important lipid molecule and is needed for all mammalian cells. In various cell types, excess cholesterol is stored as cholesteryl esters; acyl-CoA:cholesterol acyltransferase 1 (ACAT1) plays an...
18.
Huang L, Melton E, Li H, Sohn P, Jung D, Tsai C, et al.
Am J Physiol Endocrinol Metab
. 2018 Mar;
315(3):E340-E356.
PMID: 29533741
Macrophages are phagocytes that play important roles in health and diseases. Acyl-CoA:cholesterol acyltransferase 1 (ACAT1) converts cellular cholesterol to cholesteryl esters and is expressed in many cell types. Unlike global...
19.
Wang Y, Bian Y, Luo J, Lu M, Xiong Y, Guo S, et al.
Nat Cell Biol
. 2017 Nov;
19(12):1441.
PMID: 29184177
This corrects the article DOI: 10.1038/ncb3551.
20.
Wang Y, Bian Y, Luo J, Lu M, Xiong Y, Guo S, et al.
Nat Cell Biol
. 2017 Jun;
19(7):808-819.
PMID: 28604676
Ubiquitin linkage to cysteine is an unconventional modification targeting protein for degradation. However, the physiological regulation of cysteine ubiquitylation is still mysterious. Here we found that ACAT2, a cellular enzyme...