Catherine C Y Chang
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Explore the profile of Catherine C Y Chang including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Huynh T, Fikse E, De La Torre A, Havrda M, Chang C, Chang T
Int J Mol Sci
. 2025 Jan;
25(24.
PMID: 39769453
Aging and apolipoprotein E4 () are the two most significant risk factors for late-onset Alzheimer's disease (LOAD). Compared to , disrupts cholesterol homeostasis, increases cholesteryl esters (CEs), and exacerbates neuroinflammation...
2.
Huynh T, Fikse E, Havrda M, Chang C, Chang T
bioRxiv
. 2024 Nov;
PMID: 39484620
Aging and Apolipoprotein E4 (APOE4) are the two most significant risk factors for late-onset Alzheimer's disease (LOAD). Compared to APOE3, APOE4 disrupts cholesterol homeostasis, increases cholesteryl esters (CEs), and exacerbates...
3.
Huynh T, Havrda M, Zanazzi G, Chang C, Chang T
Biomolecules
. 2024 Oct;
14(10).
PMID: 39456234
Aging is the major risk factor for Alzheimer's disease (AD). In the aged brain, myelin debris accumulates and is cleared by microglia. Phagocytosed myelin debris increases neutral lipid droplet content...
4.
Lee J, De La Torre A, Rawlinson F, Ness D, Lewis L, Hickey W, et al.
Int J Mol Sci
. 2024 Sep;
25(17).
PMID: 39273099
Cholesterol homeostasis is pivotal for cellular function. Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1), also abbreviated as SOAT1, is an enzyme responsible for catalyzing the storage of excess cholesterol to cholesteryl esters....
5.
De La Torre A, Huynh T, Chang C, Pooler D, Ness D, Lewis L, et al.
Int J Mol Sci
. 2023 Jul;
24(13).
PMID: 37446191
Cholesterol is essential for cellular function and is stored as cholesteryl esters (CEs). CEs biosynthesis is catalyzed by the enzymes acyl-CoA:cholesterol acyltransferase 1 and 2 (ACAT1 and ACAT2), with ACAT1...
6.
Li H, Huynh T, Duong M, Gow J, Chang C, Chang T
Int J Mol Sci
. 2023 Mar;
24(6).
PMID: 36982689
Cholesterol is stored as cholesteryl esters by the enzymes acyl-CoA:cholesterol acyltransferases/sterol O:acyltransferases (ACATs/SOATs). ACAT1 blockade (A1B) ameliorates the pro-inflammatory responses of macrophages to lipopolysaccharides (LPS) and cholesterol loading. However, the...
7.
Harned T, Stan R, Cao Z, Chakrabarti R, Higgs H, Chang C, et al.
Int J Mol Sci
. 2023 Mar;
24(6).
PMID: 36982602
Cholesterol is a key component of all mammalian cell membranes. Disruptions in cholesterol metabolism have been observed in the context of various diseases, including neurodegenerative disorders such as Alzheimer's disease...
8.
Rogers M, Chang C, Maue R, Melton E, Peden A, Garver W, et al.
Proc Natl Acad Sci U S A
. 2022 May;
119(18):e2201646119.
PMID: 35507892
Multiple membrane organelles require cholesterol for proper function within cells. The Niemann-Pick type C (NPC) proteins export cholesterol from endosomes to other membrane compartments, including the endoplasmic reticulum (ER), plasma...
9.
Chang T, Chang C, Harned T, De La Torre A, Lee J, Huynh T, et al.
Explor Neuroprotective Ther
. 2022 Feb;
1(3):173-184.
PMID: 35199105
Cholesterol serves as an essential lipid molecule in various membrane organelles of mammalian cells. The metabolites of cholesterol also play important functions. Acyl-coenzyme A: cholesterol acyltransferase 1 (ACAT1), also named...
10.
De La Torre A, Smith C, Granger J, Anderson F, Harned T, Havrda M, et al.
J Neurosci Methods
. 2021 Dec;
367:109437.
PMID: 34890698
Background: Acyl-CoA:cholesterol acyltransferase (ACAT) inhibitors have been considered as potential therapeutic agents to treat several diseases, including Alzheimer's disease, atherosclerosis, and cancer. While many ACAT inhibitors are readily available, methods...