Cassandra L Gorsuch
Overview
Explore the profile of Cassandra L Gorsuch including associated specialties, affiliations and a list of published articles.
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4
Citations
62
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Recent Articles
1.
Shoop W, Lape J, Trum M, Powell A, Sevigny E, Mischler A, et al.
Nat Metab
. 2023 Nov;
5(12):2169-2183.
PMID: 38036771
Nuclease-mediated editing of heteroplasmic mitochondrial DNA (mtDNA) seeks to preferentially cleave and eliminate mutant mtDNA, leaving wild-type genomes to repopulate the cell and shift mtDNA heteroplasmy. Various technologies are available,...
2.
Shoop W, Gorsuch C, Bacman S, Moraes C
J Biol Chem
. 2022 Oct;
298(11):102574.
PMID: 36209825
Mitochondrial DNA (mtDNA) is present in multiple copies and phenotypic consequences of mtDNA mutations depend on the mutant load surpassing a specific threshold. Additionally, changes in mtDNA copy number can...
3.
Gorsuch C, Nemec P, Yu M, Xu S, Han D, Smith J, et al.
Mol Ther
. 2022 May;
30(9):2909-2922.
PMID: 35581938
Persistence of chronic hepatitis B (CHB) is attributed to maintenance of the intrahepatic pool of the viral covalently closed circular DNA (cccDNA), which serves as the transcriptional template for all...
4.
Hawk M, Gorsuch C, Fagan P, Lee C, Kim S, Hamann J, et al.
Nat Cell Biol
. 2018 Feb;
20(3):272-284.
PMID: 29459781
For cancer cells to survive during extracellular matrix (ECM) detachment, they must inhibit anoikis and rectify metabolic deficiencies that cause non-apoptotic cell death. Previous studies in ECM-detached cells have linked...