Carlos T Moraes
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Explore the profile of Carlos T Moraes including associated specialties, affiliations and a list of published articles.
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153
Citations
6951
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Recent Articles
1.
Barrera-Paez J, Bacman S, Balla T, Van Booven D, Gannamedi D, Stewart J, et al.
Sci Transl Med
. 2025 Jan;
17(783):eadr0792.
PMID: 39879319
Primary mitochondrial disorders are most often caused by deleterious mutations in the mitochondrial DNA (mtDNA). Here, we used a mitochondrial DddA-derived cytosine base editor (DdCBE) to introduce a compensatory edit...
2.
Perez M, Colombo R, Real S, Branham M, Laurito S, Moraes C, et al.
bioRxiv
. 2025 Jan;
PMID: 39803420
Mitochondrial diseases, caused by mutations in either nuclear or mitochondrial DNA (mtDNA), currently have limited treatment options. For mtDNA mutations, reducing mutant-to-wild-type mtDNA ratio (heteroplasmy shift) is a promising therapeutic...
3.
Peres de Oliveira A, Navarro C, Dias P, Arguello T, Walker B, Bacman S, et al.
Proteome Sci
. 2024 Oct;
22(1):8.
PMID: 39379991
Background: NEK10, a serine/threonine/tyrosine kinase belonging to the NEK (NIMA-related kinases) family, has been associated with diverse cellular processes. However, no specific target pathways have been identified. Our previous work...
4.
Walker B, Theard L, Pinto M, Rodriguez-Silva M, Bacman S, Moraes C
EMBO Mol Med
. 2024 Aug;
16(9):2210-2232.
PMID: 39169163
Oxidative Phosphorylation (OXPHOS) defects can cause severe encephalopathies and no effective treatment exists for these disorders. To assess the ability of gene replacement to prevent disease progression, we subjected two...
5.
Moraes C
Hum Mol Genet
. 2024 May;
33(R1):R92-R99.
PMID: 38779768
The manipulation of animal mitochondrial genomes has long been a challenge due to the lack of an effective transformation method. With the discovery of specific gene editing enzymes, designed to...
6.
Gonzalez C, Nissanka N, Van Booven D, Griswold A, Moraes C
J Biol Chem
. 2024 Mar;
300(4):107128.
PMID: 38432635
Both POLG and MGME1 are needed for mitochondrial DNA (mtDNA) maintenance in animal cells. POLG, the primary replicative polymerase of the mitochondria, has an exonuclease activity (3'→5') that corrects for...
7.
Bacman S, Barrera-Paez J, Pinto M, Van Booven D, Stewart J, Griswold A, et al.
Mol Ther Nucleic Acids
. 2024 Feb;
35(1):102132.
PMID: 38404505
Mutations within mtDNA frequently give rise to severe encephalopathies. Given that a majority of these mtDNA defects exist in a heteroplasmic state, we harnessed the precision of mitochondrial-targeted TALEN (mitoTALEN)...
8.
Fragkoulis G, Hangas A, Fekete Z, Michell C, Moraes C, Willcox S, et al.
Nucleic Acids Res
. 2024 Feb;
52(6):3088-3105.
PMID: 38300793
Mitochondrial DNA (mtDNA) recombination in animals has remained enigmatic due to its uniparental inheritance and subsequent homoplasmic state, which excludes the biological need for genetic recombination, as well as limits...
9.
Ryan C, Choi J, Kang B, Herr S, Pereira C, Moraes C, et al.
Neurobiol Dis
. 2023 Dec;
190:106370.
PMID: 38049013
After spinal cord injury (SCI), infiltrating macrophages undergo excessive phagocytosis of myelin and cellular debris, forming lipid-laden foamy macrophages. To understand their role in the cellular pathology of SCI, investigation...
10.
Shoop W, Lape J, Trum M, Powell A, Sevigny E, Mischler A, et al.
Nat Metab
. 2023 Nov;
5(12):2169-2183.
PMID: 38036771
Nuclease-mediated editing of heteroplasmic mitochondrial DNA (mtDNA) seeks to preferentially cleave and eliminate mutant mtDNA, leaving wild-type genomes to repopulate the cell and shift mtDNA heteroplasmy. Various technologies are available,...