Carson C Thoreen
Overview
Explore the profile of Carson C Thoreen including associated specialties, affiliations and a list of published articles.
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37
Citations
8457
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Recent Articles
1.
Lewis C, Xie L, Bhandarkar S, Jin D, Abdallah K, Draycott A, et al.
Mol Cell
. 2024 Dec;
85(2):445-459.e5.
PMID: 39706187
mRNA therapeutics offer a potentially universal strategy for the efficient development and delivery of therapeutic proteins. Current mRNA vaccines include chemically modified nucleotides to reduce cellular immunogenicity. Here, we develop...
2.
Lewis C, Xie L, Bhandarkar S, Jin D, Abdallah K, Draycott A, et al.
bioRxiv
. 2024 Mar;
PMID: 38463950
Highlights: Measurement of >30,000 human 5' UTRs reveals a 250-fold range of translation outputSystematic mutagenesis demonstrates the causality of short (3-6nt) regulatory elementsN1-methylpseudouridine alters translation initiation in a sequence-specific mannerOptimal...
3.
van den Elzen A, Watson M, Thoreen C
PLoS Genet
. 2022 Nov;
18(11):e1010532.
PMID: 36441824
mRNA regulatory sequences control gene expression at multiple levels including translation initiation and mRNA decay. The 5' terminal sequences of mRNAs have unique regulatory potential because of their proximity to...
4.
Watson M, Thoreen C
Curr Protoc
. 2022 Jan;
2(1):e344.
PMID: 35041257
The control of mRNA stability is fundamental to gene regulation, and a deeper understanding of this post-transcriptional regulatory step can provide key insights into gene function. Measuring mRNA half-lives directly,...
5.
6.
Philippe L, Vasseur J, Debart F, Thoreen C
Nucleic Acids Res
. 2020 Jun;
48(13):7604-7605.
PMID: 32558918
No abstract available.
7.
Berman A, Thoreen C, Dedeic Z, Chettle J, Roux P, Blagden S
RNA Biol
. 2020 Apr;
18(2):207-217.
PMID: 32233986
The RNA-binding protein LARP1 has generated interest in recent years for its role in the mTOR signalling cascade and its regulation of terminal oligopyrimidine (TOP) mRNA translation. Paradoxically, some scientists...
8.
Thoreen C, Kang S, Chang J, Liu Q, Zhang J, Gao Y, et al.
J Biol Chem
. 2020 Mar;
295(9):2886.
PMID: 32111721
No abstract available.
9.
Philippe L, van den Elzen A, Watson M, Thoreen C
Proc Natl Acad Sci U S A
. 2020 Feb;
117(10):5319-5328.
PMID: 32094190
Terminal oligopyrimidine (TOP) motifs are sequences at the 5' ends of mRNAs that link their translation to the mTOR Complex 1 (mTORC1) nutrient-sensing signaling pathway. They are commonly regarded as...
10.
Melnikov S, Kwok H, Manakongtreecheep K, van den Elzen A, Thoreen C, Soll D
Mol Biol Evol
. 2019 Sep;
37(1):124-133.
PMID: 31501901
Eukaryotic cells are divided into the nucleus and the cytosol, and, to enter the nucleus, proteins typically possess short signal sequences, known as nuclear localization signals (NLSs). Although NLSs have...