Quantitative Profiling of Human Translation Initiation Reveals Regulatory Elements That Potently Affect Endogenous and Therapeutically Modified MRNAs
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Abstract
Highlights: Measurement of >30,000 human 5' UTRs reveals a 250-fold range of translation outputSystematic mutagenesis demonstrates the causality of short (3-6nt) regulatory elementsN1-methylpseudouridine alters translation initiation in a sequence-specific mannerOptimal modified 5' UTRs outperform those in the current class of mRNA vaccines.