Carrie L Lucas
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Explore the profile of Carrie L Lucas including associated specialties, affiliations and a list of published articles.
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1658
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Recent Articles
1.
Olaloye O, Gu W, Gehlhaar A, Sabuwala B, Eke C, Li Y, et al.
Sci Transl Med
. 2025 Mar;
17(788):eadr0942.
PMID: 40043141
Extremely premature infants (EPIs) who are born before 30 weeks of gestation are susceptible to infection; however, the trajectory of their peripheral immunity is poorly understood. Here, we undertook longitudinal...
2.
Bender M, Lucas C
Annu Rev Immunol
. 2025 Feb;
PMID: 39952637
Throughout biology, the pursuit of genotype-phenotype relationships has provided foundational knowledge upon which new concepts and hypotheses are built. Genetic perturbation, whether occurring naturally or in experimental settings, is the...
3.
Lanahan S, Yang L, Jones K, Qi Z, Cruz Cabrera E, Cominsky L, et al.
Nat Immunol
. 2024 Jul;
25(8):1422-1431.
PMID: 38961274
The differentiation of naive and memory B cells into antibody-secreting cells (ASCs) is a key feature of adaptive immunity. The requirement for phosphoinositide 3-kinase-delta (PI3Kδ) to support B cell biology...
4.
Lucas C
Trends Immunol
. 2024 Feb;
45(2):113-126.
PMID: 38302340
New discoveries in the field of human monogenic immune diseases highlight critical genes and pathways governing immune responses. Here, I describe how the ~500 currently defined human inborn errors of...
5.
Olyha S, OConnor S, Kribis M, Bucklin M, Uthaya Kumar D, Tyler P, et al.
J Clin Immunol
. 2024 Jan;
44(2):44.
PMID: 38231408
Defining monogenic drivers of autoinflammatory syndromes elucidates mechanisms of disease in patients with these inborn errors of immunity and can facilitate targeted therapeutic interventions. Here, we describe a cohort of...
6.
Jeffries L, Mis E, McWalter K, Donkervoort S, Brodsky N, Carpier J, et al.
Genet Med
. 2023 Nov;
26(2):101023.
PMID: 37947183
Purpose: We sought to delineate a multisystem disorder caused by recessive cysteine-rich with epidermal growth factor-like domains 1 (CRELD1) gene variants. Methods: The impact of CRELD1 variants was characterized through...
7.
Cant A, Chandra A, Munro E, Rao V, Lucas C
J Allergy Clin Immunol Pract
. 2023 Sep;
12(1):69-78.
PMID: 37777067
The phosphoinositide 3-kinase (PI3K) pathway regulates diverse cellular processes, with finely tuned PI3Kδ activity being crucial for immune cell development and function. Genetic hyperactivation of PI3Kδ causes the inborn error...
8.
Bondarenko A, Boyarchuk O, Sakovich I, Polyakova E, Migas A, Kupchinskaya A, et al.
Clin Case Rep
. 2023 Aug;
11(8):e7791.
PMID: 37601427
Key Clinical Message: Partial leukocyte adhesion deficiency type 1 (LAD-1) deficiency is extremely rare condition with milder infectious manifestation and immune system imbalance leads to increased risks of autoinflammatory complications,...
9.
Barmada A, Klein J, Ramaswamy A, Brodsky N, Jaycox J, Sheikha H, et al.
Sci Immunol
. 2023 May;
8(83):eadh3455.
PMID: 37146127
Rare immune-mediated cardiac tissue inflammation can occur after vaccination, including after SARS-CoV-2 mRNA vaccines. However, the underlying immune cellular and molecular mechanisms driving this pathology remain poorly understood. Here, we...
10.
Jaycox J, Lucas C, Yildirim I, Dai Y, Wang E, Monteiro V, et al.
Nat Commun
. 2023 Mar;
14(1):1299.
PMID: 36894554
mRNA-based vaccines dramatically reduce the occurrence and severity of COVID-19, but are associated with rare vaccine-related adverse effects. These toxicities, coupled with observations that SARS-CoV-2 infection is associated with autoantibody...