Caroline E Dewar
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Explore the profile of Caroline E Dewar including associated specialties, affiliations and a list of published articles.
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9
Citations
189
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Recent Articles
1.
Gerber M, Suppanz I, Oeljeklaus S, Niemann M, Kaser S, Warscheid B, et al.
Life Sci Alliance
. 2023 Aug;
6(11).
PMID: 37586887
The AAA-ATPase Msp1 extracts mislocalised outer membrane proteins and thus contributes to mitochondrial proteostasis. Using pulldown experiments, we show that trypanosomal Msp1 localises to both glycosomes and the mitochondrial outer...
2.
Dewar C, Oeljeklaus S, Mani J, Muhlhauser W, von Kanel C, Zimmermann J, et al.
Nat Commun
. 2022 Jun;
13(1):3084.
PMID: 35654893
Mitochondrial protein import in the parasitic protozoan Trypanosoma brucei is mediated by the atypical outer membrane translocase, ATOM. It consists of seven subunits including ATOM69, the import receptor for hydrophobic...
3.
Iyer A, Niemann M, Serricchio M, Dewar C, Oeljeklaus S, Farine L, et al.
PLoS Pathog
. 2022 May;
18(5):e1009717.
PMID: 35500022
The endoplasmic reticulum membrane complex (EMC) is a versatile complex that plays a key role in membrane protein biogenesis in the ER. Deletion of the complex has wide-ranging consequences including...
4.
Dewar C, Oeljeklaus S, Wenger C, Warscheid B, Schneider A
J Biol Chem
. 2022 Mar;
298(4):101829.
PMID: 35293314
The mitochondrial FF ATP synthase of the parasite Trypanosoma brucei has been previously studied in detail. This unusual enzyme switches direction in functionality during the life cycle of the parasite,...
5.
Dewar C, Casas-Sanchez A, Dieme C, Crouzols A, Haines L, Acosta-Serrano A, et al.
mBio
. 2022 Jan;
13(1):e0235721.
PMID: 35012336
The single-celled parasite Trypanosoma brucei is transmitted by hematophagous tsetse flies. Life cycle progression from mammalian bloodstream form to tsetse midgut form and, subsequently, infective salivary gland form depends on...
6.
Dewar C, MacGregor P, Cooper S, Gould M, Matthews K, Savill N, et al.
PLoS Pathog
. 2018 Jul;
14(7):e1007195.
PMID: 30020996
The sleeping sickness parasite Trypanosoma brucei has a complex life cycle, alternating between a mammalian host and the tsetse fly vector. A tightly controlled developmental programme ensures parasite transmission between...
7.
Muhleip A, Dewar C, Schnaufer A, Kuhlbrandt W, Davies K
Proc Natl Acad Sci U S A
. 2017 Jan;
114(5):992-997.
PMID: 28096380
We used electron cryotomography and subtomogram averaging to determine the in situ structures of mitochondrial ATP synthase dimers from two organisms belonging to the phylum euglenozoa: Trypanosoma brucei, a lethal...
8.
Schnarwiler F, Niemann M, Doiron N, Harsman A, Kaser S, Mani J, et al.
Proc Natl Acad Sci U S A
. 2014 May;
111(21):7624-9.
PMID: 24821793
Mitochondria cannot form de novo but require mechanisms allowing their inheritance to daughter cells. In contrast to most other eukaryotes Trypanosoma brucei has a single mitochondrion whose single-unit genome is...
9.
Dean S, Gould M, Dewar C, Schnaufer A
Proc Natl Acad Sci U S A
. 2013 Aug;
110(36):14741-6.
PMID: 23959897
Viability of the tsetse fly-transmitted African trypanosome Trypanosoma brucei depends on maintenance and expression of its kinetoplast (kDNA), the mitochondrial genome of this parasite and a putative target for veterinary...