Caroline A Owen
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Explore the profile of Caroline A Owen including associated specialties, affiliations and a list of published articles.
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106
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3813
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Recent Articles
1.
Zhu Y, Dutta S, Han Y, Choi D, Polverino F, Owen C, et al.
Redox Biol
. 2024 Dec;
79():103481.
PMID: 39721495
Emerging evidence suggests that lipid-laden macrophages (LLM) participate in lung damage in various clinical conditions. However, the mechanisms involved in LLM formation are not fully understood. In this study, we...
2.
Dutta S, Zhu Y, Almuntashiri S, Peh H, Zuniga J, Zhang D, et al.
Am J Physiol Lung Cell Mol Physiol
. 2024 Nov;
328(1):L60-L74.
PMID: 39585242
Tissue inhibitor of metalloproteinases-1 (TIMP-1) is a physiologic inhibitor of the matrix metalloproteinases (MMPs), but little is known about the role of TIMP-1 in regulating the pathogenesis of influenza A...
3.
Umeda M, Karino K, Satyam A, Yoshida N, Hisada R, Bhargava R, et al.
Arthritis Rheumatol
. 2024 Sep;
77(2):180-189.
PMID: 39279154
Objective: Enhanced expression of transforming growth factor (TGF) β in the kidneys of patients with lupus nephritis (LN) can lead to progressive fibrosis, resulting in end-organ damage. ADAM9 activates TGFβ1...
4.
Almuntashiri S, Dutta S, Zhu Y, Gamare S, Ramirez G, Irineo-Moreno V, et al.
Physiol Rep
. 2024 Sep;
12(17):e70047.
PMID: 39267201
Increased circulating tissue inhibitor of metalloproteinases-1 (TIMP-1) levels have been observed in patients with acute lung injury (ALI). However, the sex-specific regulation of TIMP-1 and the underlying molecular mechanisms have...
5.
Moore S, Gopichandran K, Sevier E, Gamare S, Almuntashiri S, Ramirez G, et al.
Diagnostics (Basel)
. 2024 Aug;
14(16).
PMID: 39202207
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and H1N1 viruses are inflammatory lung pathogens that can lead to acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). ALI/ARDS are...
6.
Bazzone L, Zhu J, King M, Liu G, Guo Z, MacKay C, et al.
Nat Commun
. 2024 May;
15(1):4153.
PMID: 38755212
Viral myocarditis, an inflammatory disease of the heart, causes significant morbidity and mortality. Type I interferon (IFN)-mediated antiviral responses protect against myocarditis, but the mechanisms are poorly understood. We previously...
7.
Krishnan V, Atanasova N, Aujla P, Hupka D, Owen C, Kassiri Z
Am J Physiol Heart Circ Physiol
. 2024 Apr;
327(2):H409-H416.
PMID: 38607341
Cardiac hypertrophy is a common feature in several cardiomyopathies. We previously reported that loss of ADAM15 (disintegrin and metalloproteinase 15) worsened cardiac hypertrophy and dilated cardiomyopathy following cardiac pressure overload....
8.
Rojas-Quintero J, Laucho-Contreras M, Wang X, Fucci Q, Burkett P, Kim S, et al.
JCI Insight
. 2023 Feb;
8(6).
PMID: 36787195
Low Club Cell 16 kDa protein (CC16) plasma levels are linked to accelerated lung function decline in patients with chronic obstructive pulmonary disease (COPD). Cigarette smoke-exposed (CS-exposed) Cc16-/- mice have...
9.
Extracellular vesicle-encapsulated CC16 as novel nanotherapeutics for treatment of acute lung injury
Han Y, Zhu Y, Almuntashiri S, Wang X, Somanath P, Owen C, et al.
Mol Ther
. 2023 Jan;
31(5):1346-1364.
PMID: 36635966
Acute lung injury (ALI) is still associated with high mortality. Growing evidence suggests that Club Cell Protein 16 (CC16) plays a protective role against ALI. However, the doses of recombinant...
10.
Aujla P, Hu M, Hartley B, Kranrod J, Viveiros A, Kilic T, et al.
Hypertension
. 2022 Nov;
80(1):97-110.
PMID: 36330793
Background: Myocardial hypertrophy and dilation are key features of cardiomyopathies and involve several cellular and molecular events. ADAMs (a disintegrin and metalloproteinases) are membrane-bound proteinases with diverse functions whose role...