Carol A Feghali-Bostwick
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Explore the profile of Carol A Feghali-Bostwick including associated specialties, affiliations and a list of published articles.
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80
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3485
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Recent Articles
1.
Renaud L, Wilson C, Lafyatis R, Schnapp L, Feghali-Bostwick C
iScience
. 2024 Jun;
27(6):110010.
PMID: 38868196
Systemic sclerosis (SSc) is a chronic disease characterized by fibrosis and vascular abnormalities in the skin and internal organs, including the lung. SSc-associated pulmonary fibrosis (SSc-PF) is the leading cause...
2.
Waldrep K, Rodgers J, Garrett S, Wolf B, Feghali-Bostwick C
Int J Mol Sci
. 2023 Jul;
24(14).
PMID: 37510994
Pulmonary fibrosis (PF) associated with systemic sclerosis (SSc) results in significant morbidity and mortality. We previously reported that insulin-like growth factor-II (IGF-II) is overexpressed in lung tissues and fibroblasts from...
3.
Renaud L, Waldrep K, da Silveira W, Pilewski J, Feghali-Bostwick C
Int J Mol Sci
. 2023 Feb;
24(4).
PMID: 36835058
Systemic sclerosis (SSc) is a connective tissue disorder that results in fibrosis of the skin and visceral organs. SSc-associated pulmonary fibrosis (SSc-PF) is the leading cause of death amongst SSc...
4.
Richmond J, Patel D, Watanabe T, Chen H, Martyanov V, Werner G, et al.
J Invest Dermatol
. 2023 Jan;
143(7):1138-1146.e12.
PMID: 36708947
Morphea is characterized by initial inflammation followed by fibrosis of the skin and soft tissue. Despite its substantial morbidity, the pathogenesis of morphea is poorly studied. Previous work showed that...
5.
Malaab M, Renaud L, Takamura N, Zimmerman K, da Silveira W, Ramos P, et al.
Ann Rheum Dis
. 2021 Nov;
81(2):268-277.
PMID: 34750102
Objectives: Systemic sclerosis (SSc) is a complex disease of unknown aetiology in which inflammation and fibrosis lead to multiple organ damage. There is currently no effective therapy that can halt...
6.
Kendall R, Renaud L, Baatz J, Malaab M, Nguyen X, Feghali-Bostwick C
J Proteomics
. 2021 Apr;
242:104243.
PMID: 33930553
TGFβ1 is a profibrotic mediator that contributes to a broad spectrum of pathologies, including systemic sclerosis-associated pulmonary fibrosis (SSc-PF). However, the secretome of TGFβ1-stimulated primary human normal lung (NL) fibroblasts...
7.
Pachera E, Assassi S, Salazar G, Stellato M, Renoux F, Wunderlin A, et al.
J Clin Invest
. 2020 Jul;
130(9):4888-4905.
PMID: 32603313
TGF-β is a master regulator of fibrosis, driving the differentiation of fibroblasts into apoptosis-resistant myofibroblasts and sustaining the production of extracellular matrix (ECM) components. Here, we identified the nuclear long...
8.
Wasson C, Abignano G, Hermes H, Malaab M, Ross R, Jimenez S, et al.
Ann Rheum Dis
. 2020 Feb;
79(4):507-517.
PMID: 32041748
Background: Systemic sclerosis (SSc) is characterised by autoimmune activation, tissue and vascular fibrosis in the skin and internal organs. Tissue fibrosis is driven by myofibroblasts, that are known to maintain...
9.
van de Vlekkert D, Demmers J, Nguyen X, Campos Y, Machado E, Annunziata I, et al.
Sci Adv
. 2019 Jul;
5(7):eaav3270.
PMID: 31328155
Lysosomal exocytosis is a ubiquitous process negatively regulated by neuraminidase 1 (NEU1), a sialidase mutated in the glycoprotein storage disease sialidosis. In mice, excessive lysosomal exocytosis is at the basis...
10.
Hadjicharalambous M, Roux B, Csomor E, Feghali-Bostwick C, Murray L, Clarke D, et al.
Sci Rep
. 2019 Apr;
9(1):6020.
PMID: 30988425
Phenotypic changes in lung fibroblasts are believed to contribute to the development of Idiopathic Pulmonary Fibrosis (IPF), a progressive and fatal lung disease. Long intergenic non-coding RNAs (lincRNAs) have been...