Thomas A Medsger Jr
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Explore the profile of Thomas A Medsger Jr including associated specialties, affiliations and a list of published articles.
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4560
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Recent Articles
1.
Suresh S, Charlton D, Snell E, Laffoon M, Medsger Jr T, Zhu L, et al.
Arthritis Rheumatol
. 2022 Apr;
74(9):1580-1587.
PMID: 35467794
Objective: This study was undertaken to describe clinical manifestations in patients with Th/To antibody-positive systemic sclerosis (SSc) during long-term follow-up. Methods: We performed a case-control study involving anti-Th/To antibody-positive patients...
2.
Medsger Jr T, Benedek T
J Scleroderma Relat Disord
. 2022 Apr;
4(2):83-88.
PMID: 35382394
The pathology of skin involvement in systemic sclerosis (or scleroderma) was first described in detail in 1892. In this article, we trace the history of cutaneous scleroderma and the evolution...
3.
Gourh P, Safran S, Alexander T, Boyden S, Morgan N, Shah A, et al.
Proc Natl Acad Sci U S A
. 2019 Dec;
117(1):552-562.
PMID: 31871193
Systemic sclerosis (SSc) is a clinically heterogeneous autoimmune disease characterized by mutually exclusive autoantibodies directed against distinct nuclear antigens. We examined associations in SSc and its autoantibody subsets in a...
4.
Ramos P, Zimmerman K, Haddad S, Langefeld C, Medsger Jr T, Feghali-Bostwick C
Clin Epigenetics
. 2019 Apr;
11(1):58.
PMID: 30947741
Background: Systemic sclerosis (SSc) is a rare autoimmune fibrosing disease with an incompletely understood genetic and non-genetic etiology. Defining its etiology is important to allow the development of effective predictive,...
5.
Baker Frost D, Wolf B, Peoples C, Fike J, Silver K, Laffoon M, et al.
Arthritis Res Ther
. 2019 Apr;
21(1):85.
PMID: 30940202
Background: Systemic sclerosis (SSc) is a female-predominant disease, characterized by excessive extracellular matrix deposition (ECM) with dermal and internal organ fibrosis. Considering the sex-based disparity in disease incidence, estradiol (E2),...
6.
Gourh P, Remmers E, Boyden S, Alexander T, Morgan N, Shah A, et al.
Arthritis Rheumatol
. 2018 May;
70(10):1654-1660.
PMID: 29732714
Objective: Whole-exome sequencing (WES) studies in systemic sclerosis (SSc) patients of European American (EA) ancestry have identified variants in the ATP8B4 gene and enrichment of variants in genes in the...
7.
Morgan N, Shah A, Mayes M, Domsic R, Medsger Jr T, Steen V, et al.
Medicine (Baltimore)
. 2018 Feb;
96(51):e8980.
PMID: 29390428
Racial differences exist in the severity of systemic sclerosis (SSc). To enhance our knowledge about SSc in African Americans, we established a comprehensive clinical database from the largest multicenter cohort...
8.
Peoples C, Medsger Jr T, Lucas M, Rosario B, Feghali-Bostwick C
J Scleroderma Relat Disord
. 2017 Dec;
1(2):177-240.
PMID: 29242839
Introduction: There is a strong female preponderance reported in many connective tissue diseases and in almost all systemic sclerosis (SSc) case series. Methods: We compared gender differences in SSc patients...
9.
Cascio S, Medsger Jr T, Hawse W, Watkins S, Milcarek C, Moreland L, et al.
J Allergy Clin Immunol
. 2017 Nov;
142(1):109-119.e6.
PMID: 29155097
Background: IL-13-producing CD8 T cells have been implicated in the pathogenesis of type 2-driven inflammatory human conditions. We have shown that CD8IL-13 cells play a critical role in cutaneous fibrosis,...
10.
Li G, Larregina A, Domsic R, Stolz D, Medsger Jr T, Lafyatis R, et al.
J Invest Dermatol
. 2016 Dec;
137(5):1042-1050.
PMID: 28012718
Loss of CD28 expression by CD8 T cells occurs with age and during chronic inflammatory conditions. CD8CD28 T cells are a heterogeneous cell subpopulation whose function ranges from immunosuppressive to...