Carlos Carmona-Fontaine
Overview
Explore the profile of Carlos Carmona-Fontaine including associated specialties, affiliations and a list of published articles.
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26
Citations
1597
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Recent Articles
1.
Guzelsoy G, Elorza S, Ros M, Schachtner L, Hayashi M, Hobson-Gutierrez S, et al.
Nature
. 2025 Feb;
PMID: 39972131
The survival of malignant cells within tumours is often seen as depending on ruthless competition for nutrients and other resources. Although competition is certainly critical for tumour evolution and cancer...
2.
Anandi L, Garcia J, Ros M, Janska L, Liu J, Carmona-Fontaine C
Life Sci Alliance
. 2024 Oct;
8(1).
PMID: 39419548
Ischemic conditions such as hypoxia and nutrient starvation, together with interactions with stromal cells, are critical drivers of metastasis. These conditions arise deep within tumor tissues, and thus, observing nascent...
3.
Schworer S, Cimino F, Ros M, Tsanov K, Ng C, Lowe S, et al.
Cancer Res
. 2023 Mar;
83(10):1596-1610.
PMID: 36912618
Significance: Hypoxia in the tumor microenvironment of pancreatic cancer potentiates the cytokine-induced inflammatory CAF phenotype and promotes tumor growth. See related commentary by Fuentes and Taniguchi, p. 1560.
4.
Anandi L, Garcia J, Ros M, Janska L, Liu J, Carmona-Fontaine C
bioRxiv
. 2023 Jan;
PMID: 36712084
Metabolic conditions such as hypoxia, nutrient starvation, and media acidification, together with interactions with stromal cells are critical drivers of metastasis. Since these conditions arise deep within tumor tissues with...
5.
Janska L, Anandi L, Kirchberger N, Marinkovic Z, Schachtner L, Guzelsoy G, et al.
Dis Model Mech
. 2021 Aug;
14(8).
PMID: 34407185
There is an urgent need for accurate, scalable and cost-efficient models of the tumor microenvironment. Here, we detail how to fabricate and use the metabolic microenvironment chamber (MEMIC) - a...
6.
Deforet M, Carmona-Fontaine C, Korolev K, Xavier J
Am Nat
. 2019 Sep;
194(3):291-305.
PMID: 31553215
Predicting the evolution of expanding populations is critical to controlling biological threats such as invasive species and cancer metastasis. Expansion is primarily driven by reproduction and dispersal, but nature abounds...
7.
Morris 4th J, Yashinskie J, Koche R, Chandwani R, Tian S, Chen C, et al.
Nature
. 2019 Sep;
573(7775):595-599.
PMID: 31534224
The tumour suppressor TP53 is mutated in the majority of human cancers, and in over 70% of pancreatic ductal adenocarcinoma (PDAC). Wild-type p53 accumulates in response to cellular stress, and...
8.
Hobson-Gutierrez S, Carmona-Fontaine C
Dis Model Mech
. 2018 Jul;
11(8).
PMID: 29991530
The extracellular space of solid tumors ranges from being well-nurtured to being completely ischemic and can serve as a source of intratumoral heterogeneity, determining the behavior and molecular profiles of...
9.
Intlekofer A, Wang B, Liu H, Shah H, Carmona-Fontaine C, Rustenburg A, et al.
Nat Chem Biol
. 2017 Mar;
13(5):494-500.
PMID: 28263965
The metabolite 2-hydroxyglutarate (2HG) can be produced as either a D-R- or L-S- enantiomer, each of which inhibits α-ketoglutarate (αKG)-dependent enzymes involved in diverse biologic processes. Oncogenic mutations in isocitrate...
10.
Carmona-Fontaine C, Deforet M, Akkari L, Thompson C, Joyce J, Xavier J
Proc Natl Acad Sci U S A
. 2017 Mar;
114(11):2934-2939.
PMID: 28246332
The genetic and phenotypic diversity of cells within tumors is a major obstacle for cancer treatment. Because of the stochastic nature of genetic alterations, this intratumoral heterogeneity is often viewed...