Carlie Delaine
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Explore the profile of Carlie Delaine including associated specialties, affiliations and a list of published articles.
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13
Citations
215
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Recent Articles
1.
Liu M, Li Q, Delaine C, Wu H, Arsenakis Y, White B, et al.
ACS Omega
. 2023 Apr;
8(15):13715-13720.
PMID: 37091377
Commercially available insulins are manufactured by recombinant methods for the treatment of diabetes. Long-acting insulin drugs (e.g., detemir and degludec) are obtained by fatty acid conjugation at LysB29 ε-amine of...
2.
Xu Y, Margetts M, Venugopal H, Menting J, Kirk N, Croll T, et al.
Structure
. 2022 Jun;
30(8):1098-1108.e6.
PMID: 35660159
Monomers of the insulin receptor and type 1 insulin-like growth factor receptor (IGF-1R) can combine stochastically to form heterodimeric hybrid receptors. These hybrid receptors display ligand binding and signaling properties...
3.
Blyth A, Ortiz M, Merriman A, Delaine C, Forbes B
Sci Rep
. 2022 Mar;
12(1):4695.
PMID: 35304516
Insulin like growth factor II (IGF-II) is involved in metabolic and mitogenic signalling in mammalian cells and plays important roles in normal fetal development and postnatal growth. It is structurally...
4.
Xiong X, Blakely A, Kim J, Menting J, Schafer I, Schubert H, et al.
Nat Chem Biol
. 2022 Mar;
18(5):511-519.
PMID: 35289328
Cone snail venoms contain a wide variety of bioactive peptides, including insulin-like molecules with distinct structural features, binding modes and biochemical properties. Here, we report an active humanized cone snail...
5.
Mitchell M, Hossain M, Lin F, Pinheiro-Junior E, Peigneur S, Wai D, et al.
Biomolecules
. 2021 Dec;
11(12).
PMID: 34944429
The role of insulin and insulin-like peptides (ILPs) in vertebrate animals is well studied. Numerous ILPs are also found in invertebrates, although there is uncertainty as to the function and...
6.
Liu M, White B, Praveen P, Li W, Lin F, Wu H, et al.
J Med Chem
. 2021 Nov;
64(23):17448-17454.
PMID: 34797669
The growing epidemic of diabetes means that there is a need for therapies that are more efficacious, safe, and convenient. Here, we report the efficient synthesis of a novel disulfide...
7.
Ong S, Belgi A, van Lierop B, Delaine C, Andrikopoulos S, MacRaild C, et al.
J Biol Chem
. 2018 Jun;
293(30):11928-11943.
PMID: 29899115
The development of fast-acting and highly stable insulin analogues is challenging. Insulin undergoes structural transitions essential for binding and activation of the insulin receptor (IR), but these conformational changes can...
8.
van Lierop B, Ong S, Belgi A, Delaine C, Andrikopoulos S, Haworth N, et al.
Sci Rep
. 2017 Dec;
7(1):17239.
PMID: 29222417
The structural transitions required for insulin to activate its receptor and initiate regulation of glucose homeostasis are only partly understood. Here, using ring-closing metathesis, we substitute the A6-A11 disulfide bond...
9.
Alvino C, Ong S, McNeil K, Delaine C, Booker G, Wallace J, et al.
PLoS One
. 2011 Dec;
6(11):e27488.
PMID: 22140443
Background: Insulin-like growth factor-II (IGF-II) promotes cell proliferation and survival and plays an important role in normal fetal development and placental function. IGF-II binds both the insulin-like growth factor receptor...
10.
A novel approach to identify two distinct receptor binding surfaces of insulin-like growth factor II
Alvino C, McNeil K, Ong S, Delaine C, Booker G, Wallace J, et al.
J Biol Chem
. 2009 Jan;
284(12):7656-64.
PMID: 19139090
Very little is known about the residues important for the interaction of insulin-like growth factor II (IGF-II) with the type 1 IGF receptor (IGF-1R) and the insulin receptor (IR). Insulin,...