Michael C Lawrence
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Explore the profile of Michael C Lawrence including associated specialties, affiliations and a list of published articles.
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93
Citations
3191
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Recent Articles
1.
Darden C, Mohammed A, Kirkland J, Kuncha J, Lawrence M, Sebastian Danobeitia J, et al.
J Gastrointest Surg
. 2024 Jun;
28(8):1309-1318.
PMID: 38834105
Purpose: Total pancreatectomy with islet autotransplantation (TPIAT) is an effective treatment for patients with chronic pancreatitis (CP) when other interventions are unsuccessful. CP has many etiologies including heredity. Metabolic and...
2.
Mattke J, Darden C, Lawrence M, Kuncha J, Shah Y, Kane R, et al.
Front Immunol
. 2024 Apr;
15:1362727.
PMID: 38585277
Acute pancreatitis is a complex inflammatory disease resulting in extreme pain and can result in significant morbidity and mortality. It can be caused by several factors ranging from genetics, alcohol...
3.
Mattke J, Darden C, Vasu S, Lawrence M, Kirkland J, Kane R, et al.
Cells
. 2024 Mar;
13(5.
PMID: 38474380
Islet transplantation is a therapeutic option to replace β-cell mass lost during type 1 or type 3c diabetes. Innate immune responses, particularly the instant blood-mediated inflammatory reaction and activation of...
4.
Vasu S, Saracino G, Darden C, Kumano K, Liu Y, Lawrence M, et al.
Clin Transl Med
. 2023 Oct;
13(10):e1434.
PMID: 37846205
Background: Specific microRNAs (miRNAs) were elevated in chronic pancreatitis (CP) patients during islet infusion after total pancreatectomy (TPIAT). We aimed to identify circulating miRNA signatures of pancreatic damage, predict miRNA-mRNA...
5.
Moreau F, Kirk N, Zhang F, Gelfanov V, List E, Chrudinova M, et al.
Nat Commun
. 2022 Nov;
13(1):6700.
PMID: 36335114
Lymphocystis disease virus-1 (LCDV-1) and several other Iridoviridae encode viral insulin/IGF-1 like peptides (VILPs) with high homology to human insulin and IGFs. Here we show that while single-chain (sc) and...
6.
Smith N, Menting J, Weiss M, Lawrence M, Smith B
Biophys J
. 2022 Oct;
121(21):4063-4077.
PMID: 36181268
Insulin is a mainstay of therapy for diabetes mellitus, yet its thermal stability complicates global transportation and storage. Cold-chain transport, coupled with optimized formulation and materials, prevents to some degree...
7.
Kirk N, Chen Q, Wu Y, Asante A, Hu H, Espinosa J, et al.
Nat Commun
. 2022 Sep;
13(1):5695.
PMID: 36171189
The human insulin receptor signalling system plays a critical role in glucose homeostasis. Insulin binding brings about extensive conformational change in the receptor extracellular region that in turn effects trans-activation...
8.
Xu Y, Margetts M, Venugopal H, Menting J, Kirk N, Croll T, et al.
Structure
. 2022 Jun;
30(8):1098-1108.e6.
PMID: 35660159
Monomers of the insulin receptor and type 1 insulin-like growth factor receptor (IGF-1R) can combine stochastically to form heterodimeric hybrid receptors. These hybrid receptors display ligand binding and signaling properties...
9.
Liu Y, Vasu S, Kumano K, Sorelle J, Lawrence M, Naziruddin B
J Gastrointest Surg
. 2022 May;
26(8):1766-1768.
PMID: 35641811
No abstract available.
10.
Darden C, Vasu S, Mattke J, Liu Y, Rhodes C, Naziruddin B, et al.
iScience
. 2022 Apr;
25(4):104125.
PMID: 35402865
Pancreatic islets respond to metabolic and inflammatory stress by producing hormones and other factors that induce adaptive cellular and systemic responses. Here we show that intracellular Ca ([Ca]) and ROS...