Carl Westmoreland
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Explore the profile of Carl Westmoreland including associated specialties, affiliations and a list of published articles.
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28
Citations
227
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Recent Articles
11.
Laroche C, Annys E, Bender H, Botelho D, Botham P, Brendler-Schwaab S, et al.
Regul Toxicol Pharmacol
. 2019 Sep;
108:104470.
PMID: 31479718
The European Partnership for Alternative Approaches to Animal Testing (EPAA) convened a Partners' Forum on repeated dose toxicity (RDT) testing to identify synergies between industrial sectors and stakeholders along with...
12.
Barroso J, Ahn I, Caldeira C, Carmichael P, Casey W, Coecke S, et al.
Adv Exp Med Biol
. 2016 Sep;
856:343-386.
PMID: 27671730
The development and validation of scientific alternatives to animal testing is important not only from an ethical perspective (implementation of 3Rs), but also to improve safety assessment decision making with...
13.
Zhang T, Zhang Q, Guo J, Yuan H, Peng H, Cui L, et al.
Environ Toxicol Pharmacol
. 2016 Jul;
46:71-79.
PMID: 27438896
Mitochondrial dysfunction has been implicated in acute, severe liver injury caused by overdose of acetaminophen (APAP). However, whether mitochondrial biogenesis is involved is unclear. Here we demonstrated that mitochondrial biogenesis,...
14.
Yuan H, Zhang Q, Guo J, Zhang T, Zhao J, Li J, et al.
Toxicol Sci
. 2016 Jan;
150(2):400-17.
PMID: 26781513
Chemical toxicity testing is fast moving in a direction that relies increasingly on cell-basedin vitroassays anchored on toxicity pathways according to the toxicity testing in the 21st century vision. Identifying...
15.
Burden N, Mahony C, Muller B, Terry C, Westmoreland C, Kimber I
Toxicology
. 2015 May;
330:62-6.
PMID: 25932488
There are currently several factors driving a move away from the reliance on in vivo toxicity testing for the purposes of chemical safety assessment. Progress has started to be made...
16.
Willett C, Rae J, Goyak K, Landesmann B, Minsavage G, Westmoreland C
ALTEX
. 2014 Jun;
31(4):407-21.
PMID: 24954301
The Human Toxicology Project Consortium (HTPC) was created to accelerate implementation of the science and policies required to achieve a pathway-based foundation for toxicology as articulated in the 2007 National...
17.
Westmoreland C, Carmichael P
Nat Biotechnol
. 2014 Jun;
32(6):541-3.
PMID: 24911497
No abstract available.
18.
Adeleye Y, Andersen M, Clewell R, Davies M, Dent M, Edwards S, et al.
Toxicology
. 2014 Mar;
332:102-11.
PMID: 24582757
Risk assessment methodologies in toxicology have remained largely unchanged for decades. The default approach uses high dose animal studies, together with human exposure estimates, and conservative assessment (uncertainty) factors or...
19.
Willett C, Rae J, Goyak K, Minsavage G, Westmoreland C, Andersen M, et al.
ALTEX
. 2014 Feb;
31(4):500-19.
PMID: 24535319
A workshop sponsored by the Human Toxicology Project Consortium (HTPC), "Building Shared Experience to Advance Practical Application of Pathway-Based Toxicology: Liver Toxicity Mode-of-Action" brought together experts from a wide range...
20.
Kimber I, Humphris C, Westmoreland C, Alepee N, Dal Negro G, Manou I
J Appl Toxicol
. 2011 Mar;
31(3):206-9.
PMID: 21404310
There is a continuing interest in, and increasing imperatives for, the development of alternative methods for toxicological evaluations that do not require the use of animals. Although a significant investment...