Carl R Flannery
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Explore the profile of Carl R Flannery including associated specialties, affiliations and a list of published articles.
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39
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1664
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Recent Articles
1.
Flannery C, Buddin K, Begum L, Nasert M, Catalfamo B, Semler E, et al.
Cartilage
. 2023 Mar;
14(4):467-472.
PMID: 36912174
Objective: This study was conducted to compare therapeutically relevant properties of platelet-rich plasma (PRP), a commonly used autologous intra-articular treatment for osteoarthritis (OA), with those of a novel placental tissue...
2.
Shu C, Flannery C, Little C, Melrose J
Int J Mol Sci
. 2019 Feb;
20(3).
PMID: 30700002
Background: Cartilage regeneration requires a balance of anabolic and catabolic processes. Aim: To examine the susceptibility of fibromodulin (FMOD) and lumican (LUM) to degradation by MMP-13, ADAMTS-4 and ADAMTS-5, the...
3.
Leighton R, Fitzpatrick J, Smith H, Crandall D, Flannery C, Conrozier T
Open Access Rheumatol
. 2018 Jun;
10:43-54.
PMID: 29849470
Background: Pain and limitations in joint mobility associated with knee osteoarthritis (OA) are clinically challenging to manage, and advanced progression of disease can often lead to total knee arthroplasty. Intra-articular...
4.
Roberts S, Menage J, Flannery C, Richardson J
Cartilage
. 2015 Jun;
1(4):298-305.
PMID: 26069560
Objective: To determine if lubricin was present in the surface layer of repair cartilage formed after autologous chondrocyte implantation (ACI). Design: Forty-three biopsies of repair tissue were taken from patients...
5.
Graham J, Chamberland A, Lin Q, Li X, Dai D, Zeng W, et al.
PLoS One
. 2013 Sep;
8(9):e74094.
PMID: 24040176
HTRA1 is a member of the High Temperature Requirement (HTRA1) family of serine proteases, which play a role in several biological and pathological processes. In part, HTRA1 regulation occurs by...
6.
Vugmeyster Y, Wang Q, Xu X, Harrold J, Daugusta D, Li J, et al.
AAPS J
. 2012 Jan;
14(1):97-104.
PMID: 22228117
We have recently demonstrated that intra-articular (IA) administration of human recombinant lubricin, LUB:1, significantly inhibited cartilage degeneration and pain in the rat meniscal tear model of post-traumatic arthritis. In this...
7.
Lord M, Estrella R, Chuang C, Youssef P, Karlsson N, Flannery C, et al.
Connect Tissue Res
. 2011 Oct;
53(2):132-41.
PMID: 21966936
Lubricin, also referred to as superficial zone protein, has been reported to be a proteoglycan. However, the structure of its glycosaminoglycan chain has not been well characterized, and this study...
8.
Patel L, Sun W, Glasson S, Morris E, Flannery C, Chockalingam P
BMC Musculoskelet Disord
. 2011 Jul;
12:164.
PMID: 21762512
Background: Tenascin-C (TN-C) is an extracellular matrix glycoprotein that is involved in tissue injury and repair processes. We analyzed TN-C expression in normal and osteoarthritic (OA) human cartilage, and evaluated...
9.
Catterall J, Stabler T, Flannery C, Kraus V
Arthritis Res Ther
. 2011 Jan;
12(6):R229.
PMID: 21194441
Introduction: Acute trauma involving the anterior cruciate ligament is believed to be a major risk factor for the development of post-traumatic osteoarthritis 10 to 20 years post-injury. In this study,...
10.
Flannery C
Curr Drug Targets
. 2010 Mar;
11(5):614-9.
PMID: 20199389
Therapeutic alleviation of the pathophysiology of osteoarthritis (OA) is a great and unmet medical challenge. At the basic science level, significant progress has facilitated the identification of distinct pathways and...