Carina C de Oliveira Mann
Overview
Explore the profile of Carina C de Oliveira Mann including associated specialties, affiliations and a list of published articles.
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24
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1462
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Recent Articles
1.
Wenzl S, de Oliveira Mann C
FEBS Lett
. 2024 Mar;
598(8):839-863.
PMID: 38453162
Cyclic nucleotides are the most diversified category of second messengers and are found in all organisms modulating diverse pathways. While cAMP and cGMP have been studied over 50 years, cyclic...
2.
Wolf C, Lim E, Mokhtari M, Kind B, Odainic A, Lara-Villacanas E, et al.
Sci Immunol
. 2024 Jan;
9(92):eadi9769.
PMID: 38207055
UNC93B1 is critical for trafficking and function of nucleic acid-sensing Toll-like receptors (TLRs) TLR3, TLR7, TLR8, and TLR9, which are essential for antiviral immunity. Overactive TLR7 signaling induced by recognition...
3.
Hirschenberger M, Lepelley A, Rupp U, Klute S, Hunszinger V, Koepke L, et al.
Nat Commun
. 2023 Nov;
14(1):6770.
PMID: 37914730
Type I interferon (IFN) signalling is tightly controlled. Upon recognition of DNA by cyclic GMP-AMP synthase (cGAS), stimulator of interferon genes (STING) translocates along the endoplasmic reticulum (ER)-Golgi axis to...
4.
Li Y, Slavik K, Toyoda H, Morehouse B, de Oliveira Mann C, Elek A, et al.
Cell
. 2023 Jun;
186(15):3261-3276.e20.
PMID: 37379839
Cyclic GMP-AMP synthase (cGAS) is an enzyme in human cells that controls an immune response to cytosolic DNA. Upon binding DNA, cGAS synthesizes a nucleotide signal 2'3'-cGAMP that activates STING-dependent...
5.
Li Y, Slavik K, Morehouse B, de Oliveira Mann C, Mears K, Liu J, et al.
bioRxiv
. 2023 Mar;
PMID: 36865129
cGAS (cyclic GMP-AMP synthase) is an enzyme in human cells that controls an immune response to cytosolic DNA. Upon binding DNA, cGAS synthesizes a nucleotide signal 2'3'-cGAMP that activates the...
6.
Kessler N, Viehmann S, Krollmann C, Mai K, Kirschner K, Luksch H, et al.
J Exp Med
. 2022 Nov;
219(12).
PMID: 36367753
No abstract available.
7.
Stafford C, Gassauer A, de Oliveira Mann C, Tanzer M, Fessler E, Wefers B, et al.
Nature
. 2022 Aug;
609(7927):590-596.
PMID: 36002575
Bacterial cell wall components provide various unique molecular structures that are detected by pattern recognition receptors (PRRs) of the innate immune system as non-self. Most bacterial species form a cell...
8.
Kessler N, Viehmann S, Krollmann C, Mai K, Kirschner K, Luksch H, et al.
J Exp Med
. 2022 Aug;
219(10).
PMID: 35997679
Autoimmune vasculitis is a group of life-threatening diseases, whose underlying pathogenic mechanisms are incompletely understood, hampering development of targeted therapies. Here, we demonstrate that patients suffering from anti-neutrophil cytoplasmic antibodies...
9.
Bekere I, de Oliveira Mann C
Immunity
. 2022 Aug;
55(8):1329-1331.
PMID: 35947974
FoxP3 is critical for regulatory T cell function and, thus, overall immune homeostasis. In this issue of Immunity, Leng et al. reveal how FoxP3 achieves specific recognition of DNA and...
10.
Boehmer D, Formisano S, de Oliveira Mann C, Mueller S, Kluge M, Metzger P, et al.
Sci Immunol
. 2021 Jul;
6(61).
PMID: 34272227
Cytoplasmic double-stranded RNA is sensed by RIG-I-like receptors (RLRs), leading to induction of type I interferons (IFN-Is), proinflammatory cytokines, and apoptosis. Here, we elucidate signaling mechanisms that lead to cytokine...