Carina C de Oliveira Mann
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Explore the profile of Carina C de Oliveira Mann including associated specialties, affiliations and a list of published articles.
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24
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1462
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Recent Articles
11.
de Oliveira Mann C, Hopfner K
EMBO J
. 2021 Jul;
40(16):e108293.
PMID: 34250619
cGAS, an innate immune sensor of cellular stress, recognizes double-stranded DNA mislocalized in the cytosol upon infection, mitochondrial stress, DNA damage, or malignancy. Early models suggested that cytosolic localization of...
12.
de Oliveira Mann C, Hornung V
Eur J Immunol
. 2021 Jun;
51(8):1897-1910.
PMID: 34138462
Nucleic acids (NAs) represent one of the most important classes of molecules recognized by the innate immune system. However, NAs are not limited to pathogens, but are also present within...
13.
Michalski S, de Oliveira Mann C, Stafford C, Witte G, Bartho J, Lammens K, et al.
Nature
. 2020 Sep;
587(7835):678-682.
PMID: 32911480
Cyclic GMP-AMP synthase (cGAS) is an innate immune sensor for cytosolic microbial DNA. After binding DNA, cGAS synthesizes the messenger 2'3'-cyclic GMP-AMP (cGAMP), which triggers cell-autonomous defence and the production...
14.
de Oliveira Mann C, Orzalli M, King D, Kagan J, Lee A, Kranzusch P
Cell Rep
. 2019 Apr;
27(4):1165-1175.e5.
PMID: 31018131
Stimulator of interferon genes (STING) is a key regulator of type I interferon and pro-inflammatory responses during infection, cellular stress, and cancer. Here, we reveal a mechanism for how STING...
15.
Whiteley A, Eaglesham J, de Oliveira Mann C, Morehouse B, Lowey B, Nieminen E, et al.
Nature
. 2019 Feb;
567(7747):194-199.
PMID: 30787435
Cyclic dinucleotides (CDNs) have central roles in bacterial homeostasis and virulence by acting as nucleotide second messengers. Bacterial CDNs also elicit immune responses during infection when they are detected by...
16.
Zhou W, Whiteley A, de Oliveira Mann C, Morehouse B, Nowak R, Fischer E, et al.
Cell
. 2018 Jul;
174(2):300-311.e11.
PMID: 30007416
Cyclic GMP-AMP synthase (cGAS) recognition of cytosolic DNA is critical for immune responses to pathogen replication, cellular stress, and cancer. Existing structures of the mouse cGAS-DNA complex provide a model...
17.
Andreeva L, Hiller B, Kostrewa D, Lassig C, de Oliveira Mann C, Drexler D, et al.
Nature
. 2017 Sep;
549(7672):394-398.
PMID: 28902841
Cytosolic DNA arising from intracellular pathogens triggers a powerful innate immune response. It is sensed by cyclic GMP-AMP synthase (cGAS), which elicits the production of type I interferons by generating...
18.
de Oliveira Mann C, Kranzusch P
Trends Cell Biol
. 2017 Sep;
27(10):697-698.
PMID: 28882413
DNA damage elicits a potent proinflammatory immune response. A collection of four papers now reveals that micronuclear DNA is a new cell intrinsic immunostimulatory molecule, and that accumulation of the...
19.
Stahl E, Praetorius F, de Oliveira Mann C, Hopfner K, Dietz H
ACS Nano
. 2016 Sep;
10(10):9156-9164.
PMID: 27583560
One key goal of DNA nanotechnology is the bottom-up construction of macroscopic crystalline materials. Beyond applications in fields such as photonics or plasmonics, DNA-based crystal matrices could possibly facilitate the...
20.
de Oliveira Mann C, Kiefersauer R, Witte G, Hopfner K
Sci Rep
. 2016 Jun;
6:27498.
PMID: 27271801
The exceptionally conserved metazoan MAB21 proteins are implicated in cell fate decisions and share considerable sequence homology with the cyclic GMP-AMP synthase. cGAS is the major innate immune sensor for...