Calley L Hirsch
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Explore the profile of Calley L Hirsch including associated specialties, affiliations and a list of published articles.
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12
Citations
460
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Recent Articles
1.
Oatway C, Hirsch C, Gregorieff A
Methods Mol Biol
. 2018 Mar;
1765:315-331.
PMID: 29589318
The development of intestinal organoid technology has greatly accelerated research in the field of colorectal cancer. Contrary to traditional cancer cell lines, organoids are composed of multiple cell types arranged...
2.
Han H, Braunschweig U, Gonatopoulos-Pournatzis T, Weatheritt R, Hirsch C, Ha K, et al.
Mol Cell
. 2017 Feb;
65(3):539-553.e7.
PMID: 28157508
Networks of coordinated alternative splicing (AS) events play critical roles in development and disease. However, a comprehensive knowledge of the factors that regulate these networks is lacking. We describe a...
3.
Hirsch C, Wrana J, Dent S
J Mol Biol
. 2016 Oct;
429(13):1958-1977.
PMID: 27720985
Development is generally regarded as a unidirectional process that results in the acquisition of specialized cell fates. During this process, cellular identity is precisely defined by signaling cues that tailor...
4.
Shnitsar I, Bashkurov M, Masson G, Ogunjimi A, Mosessian S, Cabeza E, et al.
Nat Commun
. 2015 Sep;
6:8388.
PMID: 26399523
Cilia are hair-like cellular protrusions important in many aspects of eukaryotic biology. For instance, motile cilia enable fluid movement over epithelial surfaces, while primary (sensory) cilia play roles in cellular...
5.
Hirsch C, Akdemir Z, Wang L, Jayakumaran G, Trcka D, Weiss A, et al.
Genes Dev
. 2015 Jun;
29(12):1341.
PMID: 26109054
No abstract available.
6.
Hirsch C, Akdemir Z, Wang L, Jayakumaran G, Trcka D, Weiss A, et al.
Genes Dev
. 2015 Apr;
29(8):803-16.
PMID: 25877919
Embryonic stem cells are maintained in a self-renewing and pluripotent state by multiple regulatory pathways. Pluripotent-specific transcriptional networks are sequentially reactivated as somatic cells reprogram to achieve pluripotency. How epigenetic...
7.
David L, Hirsch C
Cell Stem Cell
. 2014 Apr;
14(4):417-8.
PMID: 24702989
Two studies by Sakurai et al. (2014) and Hu et al. (2014) in this issue of Cell Stem Cell add a new level of understanding to the mesenchymal-to-epithelial transition taking...
8.
Golipour A, David L, Liu Y, Jayakumaran G, Hirsch C, Trcka D, et al.
Cell Stem Cell
. 2012 Dec;
11(6):769-82.
PMID: 23217423
Reprogramming of somatic cells to a pluripotent state via expression of Oct4, Klf4, Myc, and Sox2 is a multistep process involving phased changes in gene expression. Here, we focus on...
9.
Hirsch C, Ellis D, Bonham K
Biochem Biophys Res Commun
. 2010 Oct;
402(4):687-92.
PMID: 20977880
Histone deacetylase inhibitors (HDACIs) are promising anti-tumor agents that selectively induce cell cycle arrest, differentiation and/or apoptosis of tumor cells. Fundamentally, HDACIs are proposed to function by activating the transcription...
10.
Koutelou E, Hirsch C, Dent S
Curr Opin Cell Biol
. 2010 Apr;
22(3):374-82.
PMID: 20363118
The SAGA complex provides a paradigm for multisubunit histone modifying complexes. Although first characterized as a histone acetyltransferase, because of the Gcn5 subunit, SAGA is now known to contain a...