C Virginio
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Explore the profile of C Virginio including associated specialties, affiliations and a list of published articles.
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21
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1109
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Recent Articles
1.
Sabat M, Raveglia L, Aldegheri L, Barilli A, Bianchi F, Brault L, et al.
Bioorg Med Chem
. 2022 Nov;
76:117084.
PMID: 36402081
This publication details the discovery of a series of selective transient receptor potential cation channel subfamily M member 5 (TRPM5) agonists culminating with the identification of the lead compound (1R,...
2.
Ballini E, Virginio C, Medhurst S, Summerfield S, Aldegheri L, Buson A, et al.
Br J Pharmacol
. 2011 Mar;
163(6):1315-25.
PMID: 21410458
Background And Purpose: P2X3 and P2X2/3 receptors are highly localized on the peripheral and central pathways of nociceptive signal transmission. The discovery of A-317491 allowed their validation as chronic inflammatory...
3.
Virginio C, MacKenzie A, North R, Surprenant A
J Physiol
. 1999 Aug;
519 Pt 2:335-46.
PMID: 10457053
1. Extracellular ATP acting on P2X7 receptors opens a channel permeable to small cations, creates an access pathway for the entry of larger molecular weight dyes, and causes cell death....
4.
Virginio C, MacKenzie A, Rassendren F, North R, Surprenant A
Nat Neurosci
. 1999 Apr;
2(4):315-21.
PMID: 10204537
P2X receptors are ligand-gated ion channels activated by the binding of extracellular adenosine 5'-triphosphate (ATP). Brief (< 1 s) applications of ATP to nodose ganglion neurons or to cells transfected...
5.
Humphreys B, Virginio C, Surprenant A, Rice J, Dubyak G
Mol Pharmacol
. 1998 Jul;
54(1):22-32.
PMID: 9658186
1-[N, O-Bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine (KN-62) and N-[1-[N-methyl-p-(5 isoquinolinesulfonyl)benzyl]-2-(4 phenylpiperazine)ethyl]-5-isoquinolinesulfonamide (KN-04) potently inhibit the human lymphocyte P2Z receptor, an ATP-gated cation channel [Br J Pharmacol 120:1483-1490 (1997)]. Although the molecular identity of the...
6.
Virginio C, North R, Surprenant A
J Physiol
. 1998 Jun;
510 ( Pt 1):27-35.
PMID: 9625864
1. Whole-cell recordings were made from HEK 293 (human embryonic kidney) cells stably transfected with cDNAs encoding P2X2, P2X3 or both receptors (P2X2/3) and from cultured rat nodose neurones. Nodose...
7.
Virginio C, Robertson G, Surprenant A, North R
Mol Pharmacol
. 1998 Jun;
53(6):969-73.
PMID: 9614197
There are currently seven P2X receptor subunits (P2X1-7) defined by molecular cloning. The functional identification of these receptors has relied primarily on the potency of alpha,beta-methylene-ATP relative to that of...
8.
Newbolt A, Stoop R, Virginio C, Surprenant A, North R, Buell G, et al.
J Biol Chem
. 1998 Jun;
273(24):15177-82.
PMID: 9614131
Western blots of Xenopus oocyte membrane preparations showed that the apparent molecular mass of the wild type P2X2 receptor (about 65 kDa) was reduced by pretreatment with endoglycosidase H. Mutagenesis...
9.
Kawashima E, Estoppey D, Virginio C, Fahmi D, Rees S, Surprenant A, et al.
Recept Channels
. 1998 Jun;
5(2):53-60.
PMID: 9606710
The 5' untranslated leader sequence from the encephalomyocarditis virus was used to engineer bicistronic or tricistronic expression vectors encoding two subunits (P2X2 and P2X3) of an ATP-gated cation channel. Human...
10.
Thomas S, Virginio C, North R, Surprenant A
J Physiol
. 1998 May;
509 ( Pt 2):411-7.
PMID: 9575290
1. Whole-cell recordings were made from rat nodose ganglion neurones in culture and from human embryonic kidney (HEK293) cells stably transfected to express P2X2, P2X3 or both receptor subunits. We...