C R Jefcoate
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Explore the profile of C R Jefcoate including associated specialties, affiliations and a list of published articles.
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144
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1455
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Recent Articles
1.
Jefcoate C, McNamara B, Artemenko I, Yamazaki T
J Steroid Biochem Mol Biol
. 2012 Jan;
43(8):751-67.
PMID: 22217822
Transfer of cholesterol to cytochrome P450scc is generally the rate-limiting step in steroid synthesis. Depending on the steroidogenic cell, cholesterol is supplied from low or high density lipoproteins (LDL or...
2.
Njai A, Larsen M, Shi L, Jefcoate C, Czuprynski C
Toxicology
. 2010 Feb;
271(1-2):27-35.
PMID: 20171256
In this study we used colony forming unit (CFU) assays to demonstrate rapid suppression (within 6h) of lymphoid (CFU-preB) and myeloid (CFU-GM) progenitor cells in DMBA-treated mice. The duration of...
3.
Artemenko I, Zhao D, Hales D, Hales K, Jefcoate C
J Biol Chem
. 2001 Oct;
276(49):46583-96.
PMID: 11579102
The metabolism of cholesterol by cytochrome P450 side chain cleavage enzyme is hormonally regulated in steroidogenic tissues via intramitochondrial cholesterol transport. The mediating steroidogenic acute regulatory protein (StAR) is synthesized...
4.
Jefcoate C, Artemenko I, Zhao D
Endocr Res
. 2001 Feb;
26(4):663-80.
PMID: 11196443
Experiments in Y-1 and primary adrenal cells have established that basal StAR mRNA is sufficient for maximum cAMP-stimulated cholesterol metabolism providing that newly synthesized p37 StAR precursor is phosphorylated, transferred...
5.
Angus W, Campaigne Larsen M, Jefcoate C
Mol Cell Endocrinol
. 2001 Feb;
170(1-2):1-13.
PMID: 11162886
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induced erbB2 and erbB3 in estrogen receptor (ER) positive T47D (T47D+) cells, but substantially slower than the direct induction of CYP1A1 or CYP1B1. Similar maximum erbB levels were...
6.
Jefcoate C, Liehr J, Santen R, Sutter T, Yager J, Yue W, et al.
J Natl Cancer Inst Monogr
. 2000 Aug;
(27):95-112.
PMID: 10963622
Estrogen exposure represents the major known risk factor for development of breast cancer in women and is implicated in the development of prostate cancer in men. Human breast tissue has...
7.
Heidel S, Macwilliams P, Baird W, Dashwood W, Buters J, Gonzalez F, et al.
Cancer Res
. 2000 Jul;
60(13):3454-60.
PMID: 10910056
Humans are exposed to polycyclic aromatic hydrocarbons (PAHs) through many environmental pollutants, especially cigarette smoke. These chemicals cause a variety of tumors and immunotoxic effects, as a consequence of bioactivation...
8.
Alexander D, Zhang L, Foroozesh M, Alworth W, Jefcoate C
Toxicol Appl Pharmacol
. 1999 Dec;
161(2):123-39.
PMID: 10581206
We have used polycyclic aromatic hydrocarbon (PAH) alkyne metabolism-based inhibitors to test whether CYP1B1 metabolism is linked to aryl hydrocarbon receptor (AhR) activation in mouse embryo fibroblasts (MEF). 1-ethynylpyrene (1EP)...
9.
Heidel S, Holston K, Buters J, Gonzalez F, Jefcoate C, Czupyrynski C
Mol Pharmacol
. 1999 Nov;
56(6):1317-23.
PMID: 10570060
We previously demonstrated that murine bone marrow stromal cells express high levels of cytochrome P4501B1 (CYP1B1) that metabolizes 7,12-dimethylbenza[a]anthracene (DMBA), and that DMBA activates the Ah receptor (AhR) in these...
10.
Ikegwuonu F, Jefcoate C
Mol Cell Biochem
. 1999 Sep;
198(1-2):89-100.
PMID: 10497882
Treatment of intact C3H10T1/2 cells or microsomes therefrom with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and benzanthracene (BA) enhanced CYP1B1 activity and CYP1B1 expression as revealed by elevations of CYP1B1-catalyzed DMBA metabolism, CYP1B1 apoprotein...