B C McNamara
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Explore the profile of B C McNamara including associated specialties, affiliations and a list of published articles.
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16
Citations
65
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Recent Articles
1.
Jefcoate C, McNamara B, Artemenko I, Yamazaki T
J Steroid Biochem Mol Biol
. 2012 Jan;
43(8):751-67.
PMID: 22217822
Transfer of cholesterol to cytochrome P450scc is generally the rate-limiting step in steroid synthesis. Depending on the steroidogenic cell, cholesterol is supplied from low or high density lipoproteins (LDL or...
2.
Yamazaki T, Kowluru R, McNamara B, Jefcoate C
Arch Biochem Biophys
. 1995 Apr;
318(1):131-9.
PMID: 7726553
Pregnenolone formation at P450scc in isolated rat adrenal mitochondria is determined equally by the amount of ACTH-stimulated reactive inner membrane cholesterol and by the matrix generation of NADPH. Evidence is...
3.
Kowluru R, Yamazaki T, McNamara B, Jefcoate C
Mol Cell Endocrinol
. 1995 Feb;
107(2):181-8.
PMID: 7539386
Adrenal mitochondria metabolize cholesterol at inner membrane (IM) cytochrome P450scc. Exogenous and outer membrane (OM) cholesterol are metabolized more slowly due to a limiting transfer of cholesterol from OM to...
4.
Yamazaki T, McNamara B, Jefcoate C
Mol Cell Endocrinol
. 1993 Sep;
95(1-2):1-11.
PMID: 8243798
Rat adrenal mitochondria contain approximately equal levels of P450scc and P45011 beta, each reduced by NADPH through adrenodoxin reductase (ADX-reductase) and adrenodoxin (ADX). Constitutive cholesterol side-chain cleavage (SCC) can be...
5.
McNamara B, Jefcoate C
Endocr Res
. 1991 Jan;
17(1-2):185-93.
PMID: 1879376
The relative effectiveness of succinate and isocitrate in supplying NADPH for cholesterol and deoxycorticosterone (DOC) metabolism by rat adrenal mitochondria has been investigated. As previously seen for cholesterol metabolism, isocitrate...
6.
McNamara B, Jefcoate C
Arch Biochem Biophys
. 1990 Dec;
283(2):464-71.
PMID: 2177329
Cholesterol side-chain cleavage in isolated adrenal mitochondria requires unique energy requirements that may determine not only electron transport to P450 but also cholesterol availability. In mitochondria from ACTH-treated rats, two...
7.
McNamara B, Jefcoate C
Mol Cell Endocrinol
. 1990 Oct;
73(2-3):123-34.
PMID: 2176627
Side-chain cleavage (SCC) of endogenous cholesterol in adrenal mitochondria isolated from ACTH-treated rats indicates that the size of the reactive cholesterol pool depends on the reducing precursor. At optimal concentrations...
8.
McNamara B, Jefcoate C
Arch Biochem Biophys
. 1989 Nov;
275(1):53-62.
PMID: 2554812
Cholesterol side-chain cleavage (CSCC) in isolated rat adrenal mitochondria is enhanced by prior corticotropin (ACTH) stimulation in vivo (8-fold). Part of this stimulation is retained in vitro by addition of...
9.
McNamara B, Jefcoate C
Arch Biochem Biophys
. 1988 Feb;
260(2):780-8.
PMID: 2829741
n-Hexane and cardiolipin each stimulate pregnenolone production by isolated rat adrenal mitochondria. Following corticotropin (ACTH) stimulation, mitochondrial cholesterol metabolism exhibits a fast phase lasting 2 min, followed by a 10-fold...
10.
Privalle C, McNamara B, Dhariwal M, Jefcoate C
Mol Cell Endocrinol
. 1987 Sep;
53(1-2):87-101.
PMID: 2822509
Rat adrenal mitochondria exhibit a linear 2-fold accumulation of cholesterol for 20 min following either in vivo ether stress or ACTH administration, providing cholesterol metabolism is inhibited by aminoglutethimide (AMG)....