C Patrick Reynolds
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Explore the profile of C Patrick Reynolds including associated specialties, affiliations and a list of published articles.
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182
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7606
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Recent Articles
1.
Berko E, Naranjo A, Daniels A, McNulty S, Krytska K, Druley T, et al.
J Clin Oncol
. 2025 Mar;
:JCO2402407.
PMID: 40036726
Purpose: Relapsed high-risk neuroblastomas (NBLs) are enriched for targetable mutations in and RAS-MAPK pathways, yet the prognostic effect of these aberrations and relevance of subclonal mutations at diagnosis remain undefined....
2.
Upton D, Liu J, George S, Valvi S, Ung C, Rayner B, et al.
Neuro Oncol
. 2025 Feb;
PMID: 39935375
Background: Diffuse midline glioma, characterised by H3K27 alteration (DMG), is the predominant high-grade glioma in children. It commonly originates in the brainstem, yet effective treatments for these patients remain elusive....
3.
Wolf A, Reynolds C, Barbieri E
Cancer Discov
. 2024 Dec;
14(12):2308-2311.
PMID: 39618284
The study by Grossmann and colleagues uses single-nucleus RNA sequencing in a cohort of matched high-risk neuroblastoma primary tumor samples, obtained from the same patient at diagnosis and definitive surgery,...
4.
Sanni A, Bennett A, Huang Y, Gidi I, Adeniyi M, Nwaiwu J, et al.
Cells
. 2024 Oct;
13(19).
PMID: 39404403
Gangliosides are glycosphingolipids composed of a sialylated glycan head group and a ceramide backbone. These anionic lipids form lipid rafts and play crucial roles in regulating various proteins involved in...
5.
Burrow T, Koneru B, Macha S, Sun W, Barr F, Triche T, et al.
Front Oncol
. 2024 Sep;
14:1399442.
PMID: 39224814
Introduction: Alternative lengthening of telomeres (ALT) occurs in sarcomas and ALT cancers share common mechanisms of therapy resistance or sensitivity. Telomeric DNA C-circles are self-primed circular telomeric repeats detected with...
6.
Jonnalagadda S, Duan L, Dow L, Boligala G, Kosmacek E, McCoy K, et al.
ChemMedChem
. 2024 Jul;
19(21):e202400081.
PMID: 38976686
A series of 7-substituted coumarin derivatives have been characterized as pan-aldo-keto reductase family 1C (AKR1C) inhibitors. The AKR1C family of enzymes are overexpressed in numerous cancers where they are involved...
7.
Keyel M, Furr K, Kang M, Reynolds C
J Clin Med
. 2023 Oct;
12(19).
PMID: 37834874
GD2, a disialoganglioside, is present on the surface of most neuroblastomas, as well as on some other cancers, such as melanoma and osteogenic sarcoma. The anti-GD2 antibody ch14.18 (dinutuximab) has...
8.
Boulter A, Maurer B, Pogue M, Kang M, Cho H, Knight A, et al.
Cancer Chemother Pharmacol
. 2023 May;
92(2):97-105.
PMID: 37199745
Purpose: Fenretinide (4-HPR) is a synthetic retinoid that induces cytotoxicity through dihydroceramide production. Safingol, a stereochemical-variant dihydroceramide precursor, exhibits synergistic effects when administered with fenretinide in preclinical studies. We conducted...
9.
Stachelek K, Harutyunyan N, Lee S, Beck A, Kim J, Xu L, et al.
Genes Chromosomes Cancer
. 2022 Dec;
62(5):275-289.
PMID: 36550020
Retinoblastomas form in response to biallelic RB1 mutations or MYCN amplification and progress to more aggressive and therapy-resistant phenotypes through accumulation of secondary genomic changes. Progression-related changes include recurrent somatic...
10.
Macha S, Koneru B, Burrow T, Zhu C, Savitski D, Rahman R, et al.
Cancer Res
. 2022 Aug;
82(18):3345-3358.
PMID: 35947641
Significance: This work demonstrates that constitutive activation of ATM in chemotherapy-refractory ALT cancer cells renders them hypersensitive to reactivation of p53 function by APR-246, indicating a potential strategy to overcome...