C P Ciosek Jr
Overview
Explore the profile of C P Ciosek Jr including associated specialties, affiliations and a list of published articles.
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20
Citations
149
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Recent Articles
1.
Gavai A, Sher P, Mikkilineni A, Poss K, McCann P, Girotra R, et al.
Bioorg Med Chem Lett
. 2001 Nov;
11(23):3041-4.
PMID: 11714606
A series of 4-hydroxy-3-methylsulfonanilido-1,2-diarylethylamines were prepared and evaluated for their human beta(3) adrenergic receptor agonist activity. SAR studies led to the identification of BMS-196085 (25), a potent beta(3) full agonist...
2.
Washburn W, Sher P, Poss K, Girotra R, McCann P, Gavai A, et al.
Bioorg Med Chem Lett
. 2001 Nov;
11(23):3035-9.
PMID: 11714605
Screening of the BMS collection identified 4-hydroxy-3-methylsulfonanilidoethanolamines as full beta 3 agonists. Substitution of the ethanolamine nitrogen with a benzyl group bearing a para hydrogen bond acceptor promoted beta(3) selectivity....
3.
Jamil H, Gordon D, Eustice D, Brooks C, Dickson Jr J, Chen Y, et al.
Proc Natl Acad Sci U S A
. 1996 Oct;
93(21):11991-5.
PMID: 8876250
The microsomal triglyceride (TG) transfer protein (MTP) is a heterodimeric lipid transfer protein that catalyzes the transport of triglyceride, cholesteryl ester, and phosphatidylcholine between membranes. Previous studies showing that the...
4.
Dickson Jr J, Biller S, Magnin D, Petrillo Jr E, Hillyer J, Hsieh D, et al.
J Med Chem
. 1996 Feb;
39(3):661-4.
PMID: 8576906
No abstract available.
5.
Magnin D, Biller S, Chen Y, Dickson Jr J, Fryszman O, Lawrence R, et al.
J Med Chem
. 1996 Feb;
39(3):657-60.
PMID: 8576905
No abstract available.
6.
Magnin D, Biller S, Dickson Jr J, Logan J, Lawrence R, Chen Y, et al.
J Med Chem
. 1995 Jul;
38(14):2596-605.
PMID: 7629799
Inhibitors of squalene synthase have the potential to be superior cholesterol-lowering agents. We previously disclosed that lipophilic 1,1-bisphosphonates I are potent squalene synthase inhibitors and orally active cholesterol-lowering agents in...
7.
Ciosek Jr C, Magnin D, Harrity T, Logan J, Dickson Jr J, Gordon E, et al.
J Biol Chem
. 1993 Nov;
268(33):24832-7.
PMID: 8227045
Squalene synthase catalyzes the reductive dimerization of two molecules of farnesyl diphosphate to form squalene at the final branchpoint of the cholesterol biosynthetic pathway. We report herein that isoprenyl 1,1-bisphosphonates...
8.
Robl J, Duncan L, Pluscec J, Karanewsky D, Gordon E, Ciosek Jr C, et al.
J Med Chem
. 1991 Sep;
34(9):2804-15.
PMID: 1895299
A series of 2,3,4,(5),6-substituted pyridines containing a hydroxyphosphinyl functionally have been prepared and were evaluated for their ability to inhibit the enzyme HMG-CoA reductase. Systematic substitution of both R1-R4 and...
9.
Biller S, Forster C, Gordon E, Harrity T, Rich L, Marretta J, et al.
J Med Chem
. 1991 Jun;
34(6):1912-4.
PMID: 2061928
No abstract available.
10.
Karanewsky D, Badia M, Ciosek Jr C, Robl J, Sofia M, Simpkins L, et al.
J Med Chem
. 1990 Nov;
33(11):2952-6.
PMID: 2231594
No abstract available.