C Murakata
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Explore the profile of C Murakata including associated specialties, affiliations and a list of published articles.
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Articles
22
Citations
593
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Recent Articles
1.
Soga S, Sharma S, Shiotsu Y, Shimizu M, Tahara H, Yamaguchi K, et al.
Cancer Chemother Pharmacol
. 2002 Jan;
48(6):435-45.
PMID: 11800023
Purpose: Radicicol is a novel hsp90 antagonist, distinct from the chemically unrelated benzoquinone ansamycin compounds, geldanamycin and herbimycin. Both geldanamycin and radicicol bind in the aminoterminal nucleotide-binding pocket of hsp90,...
2.
Shiotsu Y, Neckers L, Wortman I, An W, Schulte T, Soga S, et al.
Blood
. 2000 Sep;
96(6):2284-91.
PMID: 10979978
Chronic myelogenous leukemia (CML) is a clonal disorder of a pluripotent hematopoietic stem cells characterized by a chimeric bcr-abl gene giving rise to a p210(Bcr-Abl) protein with dysregulated tyrosine kinase...
3.
Shiotsu Y, Yamashita K, Kanai F, Ikuina Y, Murakata C, Teramura M, et al.
Blood
. 2000 Jun;
95(12):3771-80.
PMID: 10845909
We examined the chemoprotective effects of KF41399, a novel derivative of carbazole compounds, on severe thrombocytopenia induced by nimustine (ACNU, 45 mg/kg administered for 2 consecutive days intravenously) in mice....
4.
Amishiro N, Nagamura S, Murakata C, Okamoto A, Kobayashi E, Asada M, et al.
Bioorg Med Chem
. 2000 Mar;
8(2):381-91.
PMID: 10722161
A series of the 8-O-substituted A-ring pyrrole derivatives of duocarmycin bearing the simplified DNA-binding moieties such as cinnamoyl or heteroarylacryloyl groups were synthesized, and evaluated for in vitro anticellular activity...
5.
Pirvola U, Virkkala J, Saarma M, Murakata C, Camoratto A, Walton K, et al.
J Neurosci
. 2000 Jan;
20(1):43-50.
PMID: 10627579
We have studied the mechanisms of auditory hair cell death after insults in vitro and in vivo. We show DNA fragmentation of hair cell nuclei after ototoxic drug and intense...
6.
Amishiro N, Okamoto A, Murakata C, Tamaoki T, Okabe M, Saito H
J Med Chem
. 1999 Jul;
42(15):2946-60.
PMID: 10425104
A series of 3-substituted A-ring pyrrole compounds of duocarmycin were synthesized and evaluated for in vitro anticellular activity against HeLa S(3) cells and in vivo antitumor activity against murine sarcoma...
7.
Soga S, Neckers L, Schulte T, Shiotsu Y, Akasaka K, Narumi H, et al.
Cancer Res
. 1999 Jun;
59(12):2931-8.
PMID: 10383157
Radicicol, a macrocyclic antifungal antibiotic, has been shown to bind to the heat shock protein 90 (Hsp90) chaperone, interfering with its function. Hsp90 family chaperones have been shown to associate...
8.
George D, Dionne C, Jani J, Angeles T, Murakata C, Lamb J, et al.
Cancer Res
. 1999 May;
59(10):2395-401.
PMID: 10344749
The indolocarbazole analogue CEP-751 is a potent and selective tyrosine kinase inhibitor of the neurotrophin-specific trk receptors that has demonstrated antitumor activity in nine different models of prostate cancer growth...
9.
Saporito M, Brown E, Carswell S, DiCamillo A, Miller M, Murakata C, et al.
Neuroscience
. 1999 Jan;
86(2):461-72.
PMID: 9881861
We have identified a class of small organic molecules, derived from the indolocarbazole K-252a, that promote the survival of cultured neurons. However, many of these indolocarbazoles inhibit protein kinase C...
10.
Hudkins R, Iqbal M, Park C, Goldstein J, Herman J, Shek E, et al.
Bioorg Med Chem Lett
. 1999 Jan;
8(14):1873-6.
PMID: 9873450
Prodrug esters of the indolocarbazole CEP-751 (KT-6587) were prepared with the goal of identifying water soluble, stable but cleavable forms for intravenous dosing. A dipeptide proform Lys-beta-Ala (16, CEP-2563/KT-8391) was...