J T Isaacs
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Explore the profile of J T Isaacs including associated specialties, affiliations and a list of published articles.
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Articles
215
Citations
4249
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0
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Recent Articles
1.
Mandl A, Jasmine S, Krueger T, Kumar R, Coleman I, Dalrymple S, et al.
bioRxiv
. 2024 Feb;
PMID: 38328141
Statement Of Significance: Neuroendocrine prostate cancer presents a clinical challenge due to the lack of effective treatments. Our research demonstrates that bomedemstat, a potent and selective LSD1 inhibitor, effectively combats...
2.
3.
Bosland M, Chung L, Greenberg N, Ho S, Isaacs J, Lane K, et al.
Urol Oncol
. 2011 Jan;
2(4):99.
PMID: 21224146
No abstract available.
4.
Singh P, Uzgare A, Litvinov I, Denmeade S, Isaacs J
Endocr Relat Cancer
. 2006 Sep;
13(3):653-66.
PMID: 16954423
Prostatic carcinogenesis is associated with changes in the androgen receptor (AR) axis converting it from a paracrine dependence upon stromal signaling to an autocrine-initiated signaling for proliferation and survival of...
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6.
Tombal B, Denmeade S, Isaacs J
Cell Death Differ
. 2002 Apr;
9(5):561-73.
PMID: 11973614
Many agents, such as the endoplasmic reticulum Ca(2+) ATPase inhibitor, thapsigargin, or the ionophore, ionomycin, induce apoptosis by transiently elevating [Ca(2+)](i). The role of [Ca(2+)](i) in apoptosis induced by agents...
7.
Arnold J, Isaacs J
Endocr Relat Cancer
. 2002 Mar;
9(1):61-73.
PMID: 11914183
The acquisition of an androgen-independent phenotype by prostate cancer cells is presently a death sentence for patients. In order to have a realistic chance of changing this outcome, an understanding...
8.
Jakobsen C, Denmeade S, Isaacs J, Gady A, Olsen C, Christensen S
J Med Chem
. 2001 Dec;
44(26):4696-703.
PMID: 11741487
A series of thapsigargin (TG) analogues, containing an amino acid applicable for conjugation to a peptide specifically cleaved by prostate-specific antigen (PSA), has been prepared to develop the drug-moiety of...
9.
Pinski J, Parikh A, Bova G, Isaacs J
Cancer Res
. 2001 Aug;
61(17):6372-6.
PMID: 11522628
Osteoblastic metastases are common in lethal prostate cancer. Effective therapy for bone metastases is lacking. Thus, developing an appropriate in vitro screening system is critical to prioritize which of the...
10.
Weeraratna A, Dalrymple S, Lamb J, Denmeade S, Miknyoczki S, Dionne C, et al.
Clin Cancer Res
. 2001 Aug;
7(8):2237-45.
PMID: 11489797
During the progression of prostate cancer, molecular changes occur resulting in the autocrine production of a series of neurotrophins by the malignant cells. This is coupled with expression of high-affinity...