L G Gregory
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Explore the profile of L G Gregory including associated specialties, affiliations and a list of published articles.
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12
Citations
239
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Recent Articles
1.
Denney L, Branchett W, Gregory L, Oliver R, Lloyd C
Mucosal Immunol
. 2017 Oct;
11(2):523-535.
PMID: 29067998
Mucosal surfaces are under constant bombardment from potentially antigenic particles and so must maintain a balance between homeostasis and inappropriate immune activation and consequent pathology. Epithelial cells have a vital...
2.
Mathie S, Dixon K, Walker S, Tyrrell V, Mondhe M, ODonnell V, et al.
Allergy
. 2014 Oct;
70(1):80-9.
PMID: 25331546
Background: Alveolar macrophages are sentinels of the pulmonary mucosa and central to maintaining immunological homeostasis. However, their role in governing the response to allergen is not fully understood. Inappropriate responses...
3.
Murdoch J, Gregory L, Lloyd C
Clin Exp Allergy
. 2014 Aug;
44(11):1386-98.
PMID: 25146585
Background: γδT cells play a crucial immunoregulatory role in the lung, maintaining normal airway tone and preventing hyperresponsiveness to innocuous allergen. During acute inflammatory episodes, γδT cells promote resolution of...
4.
Gregory L, Jones C, Mathie S, Pegorier S, Lloyd C
Allergy
. 2013 Oct;
68(12):1579-88.
PMID: 24117726
Background: The current paradigm describing asthma pathogenesis recognizes the central role of abnormal epithelial function in the generation and maintenance of the disease. However, the mechanisms responsible for the initiation...
5.
Gregory L, Causton B, Murdoch J, Mathie S, ODonnell V, Thomas C, et al.
Clin Exp Allergy
. 2009 Jun;
39(10):1597-610.
PMID: 19545261
Background: Inhaled house dust mite (HDM) results in T-helper (TH) 2 type pathology in unsensitized mice, in conjunction with airway hyperreactivity and airway remodelling. However, the pulmonary cytokine and chemokine...
6.
Coutelle C, Themis M, Waddington S, Buckley S, Gregory L, Nivsarkar M, et al.
Gene Ther
. 2005 Sep;
12(22):1601-7.
PMID: 16136161
Somatic gene delivery in utero is a novel approach to gene therapy for genetic disease based on the hypothesis that prenatal intervention may avoid the development of severe manifestations of...
7.
Waddington S, Kennea N, Buckley S, Gregory L, Themis M, Coutelle C
Gene Ther
. 2004 Sep;
11 Suppl 1:S92-7.
PMID: 15454963
The current approaches to gene therapy of monogenetic diseases into mature organisms are confronted with several problems including the following: (1) the underlying genetic defect may have already caused irreversible...
8.
Gregory L, Waddington S, Holder M, Mitrophanous K, Buckley S, Mosley K, et al.
Gene Ther
. 2004 May;
11(14):1117-25.
PMID: 15141156
Gene therapy for Duchenne muscular dystrophy has so far not been successful because of the difficulty in achieving efficient and permanent gene transfer to the large number of affected muscles...
9.
Peebles D, Gregory L, David A, Themis M, Waddington S, Knapton H, et al.
Gene Ther
. 2003 Dec;
11(1):70-8.
PMID: 14681699
Cystic fibrosis is a common lethal genetic disease caused by functional absence of the cystic fibrosis transmembrane conductance regulator (CFTR). Although a candidate disease for in utero gene therapy, demonstration...
10.
Gregory L, Richardson D, Spiro S
FEMS Microbiol Lett
. 2000 Feb;
183(2):275-9.
PMID: 10675597
A nested PCR primed by four degenerate oligonucleotides was developed for the specific amplification of sequences from the narG gene encoding the membrane-bound nitrate reductase. This approach was used to...