C Leah B Kline
Overview
Explore the profile of C Leah B Kline including associated specialties, affiliations and a list of published articles.
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Articles
5
Citations
290
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0
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Recent Articles
1.
Allen J, Kline C, Prabhu V, Wagner J, Ishizawa J, Madhukar N, et al.
Oncotarget
. 2021 Oct;
12(21):2231.
PMID: 34676056
[This corrects the article DOI: 10.18632/oncotarget.11814.].
2.
Prabhu V, Madhukar N, Gilvary C, Kline C, Oster S, El-Deiry W, et al.
Clin Cancer Res
. 2018 Dec;
25(7):2305-2313.
PMID: 30559168
Purpose: Dopamine receptor D2 (DRD2) is a G protein-coupled receptor antagonized by ONC201, an anticancer small molecule in clinical trials for high-grade gliomas and other malignancies. DRD5 is a dopamine...
3.
Prabhu V, Talekar M, Lulla A, Kline C, Zhou L, Hall J, et al.
Cell Cycle
. 2017 Nov;
17(4):468-478.
PMID: 29157092
ONC201, founding member of the imipridone class of small molecules, is currently being evaluated in advancer cancer clinical trials. We explored single agent and combinatorial efficacy of ONC201 in preclinical...
4.
Allen J, Kline C, Prabhu V, Wagner J, Ishizawa J, Madhukar N, et al.
Oncotarget
. 2016 Sep;
7(45):74380-74392.
PMID: 27602582
ONC201 is the founding member of a novel class of anti-cancer compounds called imipridones that is currently in Phase II clinical trials in multiple advanced cancers. Since the discovery of...
5.
Kline C, van den Heuvel A, Allen J, Prabhu V, Dicker D, El-Deiry W
Sci Signal
. 2016 Feb;
9(415):ra18.
PMID: 26884600
ONC201 (also called TIC10) is a small molecule that inactivates the cell proliferation- and cell survival-promoting kinases Akt and ERK and induces cell death through the proapoptotic protein TRAIL. ONC201...