C Keith Cassidy
Overview
Explore the profile of C Keith Cassidy including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
521
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Recent Articles
1.
Berndsen Z, Cassidy C
Nature
. 2024 Dec;
638(8051):836-843.
PMID: 39662503
Low-density lipoprotein (LDL) has a central role in lipid and cholesterol metabolism and is a key agent in the development and progression of atherosclerosis, the leading cause of mortality worldwide....
2.
von Kugelgen A, Cassidy C, van Dorst S, Pagani L, Batters C, Ford Z, et al.
Nature
. 2024 May;
630(8015):230-236.
PMID: 38811725
Nitrosopumilus maritimus is an ammonia-oxidizing archaeon that is crucial to the global nitrogen cycle. A critical step for nitrogen oxidation is the entrapment of ammonium ions from a dilute marine...
3.
Ansell T, Song W, Coupland C, Carrique L, Corey R, Duncan A, et al.
Nat Commun
. 2023 Nov;
14(1):7774.
PMID: 38012131
Cryo-electron microscopy (cryo-EM) enables the determination of membrane protein structures in native-like environments. Characterising how membrane proteins interact with the surrounding membrane lipid environment is assisted by resolution of lipid-like...
4.
Cassidy C, Qin Z, Frosio T, Gosink K, Yang Z, Sansom M, et al.
mBio
. 2023 Sep;
14(5):e0079323.
PMID: 37772839
Bacterial chemotaxis is a ubiquitous behavior that enables cell movement toward or away from specific chemicals. It serves as an important model for understanding cell sensory signal transduction and motility....
5.
Dietz L, Ellison C, Riechmann C, Cassidy C, Felfoldi F, Pinto-Fernandez A, et al.
Science
. 2023 Feb;
379(6637):1112-1117.
PMID: 36758106
Certain inhibitor of apoptosis (IAP) family members are sentinel proteins that prevent untimely cell death by inhibiting caspases. Antagonists, including second mitochondria-derived activator of caspases (SMAC), regulate IAPs and drive...
6.
Ouyang R, Costa A, Cassidy C, Otwinowska A, Williams V, Latka A, et al.
Nat Commun
. 2022 Nov;
13(1):7241.
PMID: 36433970
The Klebsiella jumbo myophage ϕKp24 displays an unusually complex arrangement of tail fibers interacting with a host cell. In this study, we combine cryo-electron microscopy methods, protein structure prediction methods,...
7.
Hadjidemetriou K, Kaur S, Cassidy C, Zhang P
Biochem Soc Trans
. 2022 Nov;
50(6):1595-1605.
PMID: 36421737
Chemotaxis signaling pathways enable bacteria to sense and respond to their chemical environment and, in some species, are critical for lifestyle processes such as biofilm formation and pathogenesis. The signal...
8.
Zhu Y, Koo C, Cassidy C, Spink M, Ni T, Zanetti-Domingues L, et al.
Nat Commun
. 2022 Sep;
13(1):5221.
PMID: 36064719
Methane-oxidizing bacteria play a central role in greenhouse gas mitigation and have potential applications in biomanufacturing. Their primary metabolic enzyme, particulate methane monooxygenase (pMMO), is housed in copper-induced intracytoplasmic membranes...
9.
Pinas G, DeSantis M, Cassidy C, Parkinson J
Sci Signal
. 2022 Jan;
15(718):eabj1737.
PMID: 35077199
The chemoreceptor array is a supramolecular assembly that enables cells to respond to extracellular cues dynamically and with great precision and sensitivity. In the array, transmembrane receptors organized as trimers...
10.
Song W, Corey R, Ansell T, Cassidy C, Horrell M, Duncan A, et al.
J Chem Theory Comput
. 2022 Jan;
18(2):1188-1201.
PMID: 35020380
Lipids play important modulatory and structural roles for membrane proteins. Molecular dynamics simulations are frequently used to provide insights into the nature of these protein-lipid interactions. Systematic comparative analysis requires...