Benjamin A Himes
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Explore the profile of Benjamin A Himes including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
472
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Recent Articles
1.
Lucas B, Himes B, Grigorieff N
Elife
. 2023 Nov;
12.
PMID: 38010355
Previously we showed that 2D template matching (2DTM) can be used to localize macromolecular complexes in images recorded by cryogenic electron microscopy (cryo-EM) with high precision, even in the presence...
2.
Sheng Y, Harrison P, Vogirala V, Yang Z, Strain-Damerell C, Frosio T, et al.
Faraday Discuss
. 2022 Aug;
240(0):261-276.
PMID: 35938521
Developments in cryo-EM have allowed atomic or near-atomic resolution structure determination to become routine in single particle analysis (SPA). However, near-atomic resolution structures determined using cryo-electron tomography and sub-tomogram averaging...
3.
Ni T, Frosio T, Mendonca L, Sheng Y, Clare D, Himes B, et al.
Nat Protoc
. 2022 Jan;
17(2):421-444.
PMID: 35022621
Cryo-electron tomography and subtomogram averaging (STA) has developed rapidly in recent years. It provides structures of macromolecular complexes in situ and in cellular context at or below subnanometer resolution and...
4.
Lucas B, Himes B, Xue L, Grant T, Mahamid J, Grigorieff N
Elife
. 2021 Jun;
10.
PMID: 34114559
For a more complete understanding of molecular mechanisms, it is important to study macromolecules and their assemblies in the broader context of the cell. This context can be visualized at...
5.
Mendonca L, Sun D, Ning J, Liu J, Kotecha A, Olek M, et al.
Commun Biol
. 2021 Apr;
4(1):481.
PMID: 33863979
Gag is the HIV structural precursor protein which is cleaved by viral protease to produce mature infectious viruses. Gag is a polyprotein composed of MA (matrix), CA (capsid), SP1, NC...
6.
Cassidy C, Himes B, Sun D, Ma J, Zhao G, Parkinson J, et al.
Commun Biol
. 2020 Jan;
3(1):24.
PMID: 31925330
To enable the processing of chemical gradients, chemotactic bacteria possess large arrays of transmembrane chemoreceptors, the histidine kinase CheA, and the adaptor protein CheW, organized as coupled core-signaling units (CSU)....
7.
Himes B, Zhang P
Nat Methods
. 2018 Oct;
15(11):955-961.
PMID: 30349041
Macromolecular complexes are intrinsically flexible and often challenging to purify for structure determination by single-particle cryo-electron microscopy (cryo-EM). Such complexes can be studied by cryo-electron tomography (cryo-ET) combined with subtomogram...
8.
Cassidy C, Himes B, Luthey-Schulten Z, Zhang P
Curr Opin Microbiol
. 2017 Nov;
43:14-23.
PMID: 29107896
Recent advances in cryo-electron microscopy (cryoEM) have dramatically improved the resolutions at which vitrified biological specimens can be studied, revealing new structural and mechanistic insights over a broad range of...
9.
Ning J, Erdemci-Tandogan G, Yufenyuy E, Wagner J, Himes B, Zhao G, et al.
Nat Commun
. 2016 Dec;
7:13689.
PMID: 27958264
HIV-1 virions assemble as immature particles containing Gag polyproteins that are processed by the viral protease into individual components, resulting in the formation of mature infectious particles. There are two...
10.
Liu C, Perilla J, Ning J, Lu M, Hou G, Ramalho R, et al.
Nat Commun
. 2016 Mar;
7:10714.
PMID: 26940118
The host cell factor cyclophilin A (CypA) interacts directly with the HIV-1 capsid and regulates viral infectivity. Although the crystal structure of CypA in complex with the N-terminal domain of...