C J Sherr
Overview
Explore the profile of C J Sherr including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
215
Citations
19879
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
11.
Komuro H, Valentine M, Rubnitz J, Saito M, Raimondi S, Carroll A, et al.
Neoplasia
. 2000 Aug;
1(3):253-61.
PMID: 10935480
The p27KIP1 gene, which encodes a cyclin-dependent kinase (CDK) inhibitor, has been assigned to chromosome band 12p12, a region often affected by cytogenetically apparent deletions or translocations in childhood acute...
12.
Sherr C
Cancer Res
. 2000 Aug;
60(14):3689-95.
PMID: 10919634
Genetic lesions that disable key regulators of G1 phase progression in mammalian cells are present in most human cancers. Mitogen-dependent, cyclin D-dependent kinases (cdk4 and cdk6) phosphorylate the retinoblastoma (Rb)...
13.
Inoue K, Wen R, Rehg J, Adachi M, Cleveland J, Roussel M, et al.
Genes Dev
. 2000 Jul;
14(14):1797-809.
PMID: 10898794
The DMP1 transcription factor induces the ARF tumor suppressor gene in mouse fibroblasts, leading to cell cycle arrest in a p53-dependent manner. We disrupted sequences encoding the DNA-binding domain of...
14.
Groth A, Weber J, Willumsen B, Sherr C, Roussel M
J Biol Chem
. 2000 Jun;
275(35):27473-80.
PMID: 10842176
Oncogenic Ras induces two products of the INK4a/ARF tumor suppressor locus (p16(INK4a) and p19(ARF)) in primary human and rodent fibroblasts, ultimately leading to a permanent state of cell cycle arrest...
15.
Weber J, Kuo M, Bothner B, DiGiammarino E, Kriwacki R, Roussel M, et al.
Mol Cell Biol
. 2000 Mar;
20(7):2517-28.
PMID: 10713175
The ARF tumor suppressor protein stabilizes p53 by antagonizing its negative regulator, Mdm2 (Hdm2 in humans). Both mouse p19(ARF) and human p14(ARF) bind to the central region of Mdm2 (residues...
16.
Sherr C, Weber J
Curr Opin Genet Dev
. 2000 Feb;
10(1):94-9.
PMID: 10679383
The ARF tumor suppressor connects pathways regulated by the retinoblastoma protein and p53. ARF inactivation reduces p53-dependent apoptosis induced by oncogenic signals. Nucleolar relocalization of Mdm2 by ARF connotes a...
17.
Zindy F, van Deursen J, Grosveld G, Sherr C, Roussel M
Mol Cell Biol
. 1999 Dec;
20(1):372-8.
PMID: 10594039
The INK4 family of cyclin-dependent kinase (CDK) inhibitors includes four 15- to 19-kDa polypeptides (p16(INK4a), p15(INK4b), p18(INK4c), and p19(INK4d)) that bind to CDK4 and CDK6. By disrupting cyclin D-dependent holoenzymes,...
18.
Weber J, Taylor L, Roussel M, Sherr C, Bar-Sagi D
Nat Cell Biol
. 1999 Nov;
1(1):20-6.
PMID: 10559859
The Ink4/Arf locus encodes two tumour-suppressor proteins, p16Ink4a and p19Arf, that govern the antiproliferative functions of the retinoblastoma and p53 proteins, respectively. Here we show that Arf binds to the...
19.
Zindy F, Cunningham J, Sherr C, Jogal S, Smeyne R, Roussel M
Proc Natl Acad Sci U S A
. 1999 Nov;
96(23):13462-7.
PMID: 10557343
Development of the central nervous system requires proliferation of neuronal and glial cell precursors followed by their subsequent differentiation in a highly coordinated manner. The timing of neuronal cell cycle...
20.
Eischen C, Weber J, Roussel M, Sherr C, Cleveland J
Genes Dev
. 1999 Oct;
13(20):2658-69.
PMID: 10541552
Transgenic mice expressing the c-Myc oncogene driven by the immunoglobulin heavy chain enhancer (Emu) develop B-cell lymphoma and exhibit a mean survival time of approximately 6 months. The protracted latent...