C H Macphee
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Explore the profile of C H Macphee including associated specialties, affiliations and a list of published articles.
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36
Citations
988
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Recent Articles
1.
Tyurin V, Balasubramanian K, Winnica D, Tyurina Y, Vikulina A, He R, et al.
Cell Death Differ
. 2014 Jan;
21(5):825-35.
PMID: 24464221
Diversified anionic phospholipids, phosphatidylserines (PS), externalized to the surface of apoptotic cells are universal phagocytic signals. However, the role of major PS metabolites, such as peroxidized species of PS (PSox)...
2.
Macphee C
Curr Opin Pharmacol
. 2001 Nov;
1(2):121-5.
PMID: 11714085
The recognition that atherosclerosis represents an inflammatory disease has begun to shift interest towards novel therapies that could specifically target the underlying inflammatory component of atherogenesis. Like low-density lipoprotein, an...
3.
Carpenter K, Dennis I, Challis I, Osborn D, Macphee C, Leake D, et al.
FEBS Lett
. 2001 Sep;
505(3):357-63.
PMID: 11576528
The death of macrophages contributes to atheroma formation. Oxidation renders low-density lipoprotein (LDL) cytotoxic to human monocyte-macrophages. Lipoprotein-associated phospholipase A2 (Lp-PLA2), also termed platelet-activating factor acetylhydrolase, hydrolyses oxidised phospholipids. Inhibition...
4.
Vosper H, Patel L, Graham T, Khoudoli G, Hill A, Macphee C, et al.
J Biol Chem
. 2001 Sep;
276(47):44258-65.
PMID: 11557774
The peroxisome proliferator-activated receptors (PPARs) are a family of fatty acid-activated transcription factors which control lipid homeostasis and cellular differentiation. PPARalpha (NR1C1) controls lipid oxidation and clearance in hepatocytes and...
5.
Bloomer J, BOYD H, Hickey D, Ife R, Leach C, Macphee C, et al.
Bioorg Med Chem Lett
. 2001 Jul;
11(14):1925-9.
PMID: 11459662
The lipophilic 1-substituent in a series of 1-((amidolinked)-alkyl)-pyrimidones, inhibitors of recombinant lipoprotein-associated phospholipase A(2), has been modified to give inhibitors of high potency in human plasma and enhanced physicochemical properties....
6.
Patel L, Pass I, Coxon P, Downes C, Smith S, Macphee C
Curr Biol
. 2001 May;
11(10):764-8.
PMID: 11378386
The PTEN tumor suppressor gene modulates several cellular functions, including cell migration, survival, and proliferation [1] by antagonizing phosphatidylinositol 3-kinase (PI 3-kinase)-mediated signaling cascades. Mechanisms by which the expression of...
7.
Leach C, Hickey D, Ife R, Macphee C, Smith S, Tew D
Farmaco
. 2001 May;
56(1-2):45-50.
PMID: 11347966
Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a serine lipase that is associated with low density lipoprotein (LDL) in human plasma. Substrates include oxidised phosphatidylcholine (PC), which is hydrolysed by Lp-PLA2 to...
8.
Patel L, Charlton S, Chambers J, Macphee C
Cytokine
. 2001 Apr;
14(1):27-36.
PMID: 11298490
Emerging evidence indicates that chemokine receptor expression patterns are critical in determining the spectrum of action of the chemokines. We have analysed the expression patterns of 17 chemokine receptors and...
9.
BOYD H, Hammond B, Hickey D, Ife R, Leach C, Lewis V, et al.
Bioorg Med Chem Lett
. 2001 Mar;
11(5):701-4.
PMID: 11266173
Modification of the pyrimidone 5-substituent in a series of 1-((amidolinked)-alkyl)-pyrimidones, lipophilic inhibitors of lipoprotein-associated phospholipase A2, has given inhibitors of nanomolar potency and improved physicochemical properties. Compound 23 was identified...
10.
BOYD H, Fell S, FLYNN S, Hickey D, Ife R, Leach C, et al.
Bioorg Med Chem Lett
. 2000 Nov;
10(22):2557-61.
PMID: 11086729
From two related series of 2-(alkylthio)-pyrimidones, a novel series of 1-((amidolinked)-alkyl)-pyrimidones has been designed as nanomolar inhibitors of human lipoprotein-associated phospholipase A2. These compounds show greatly enhanced activity in isolated...