C Czech
Overview
Explore the profile of C Czech including associated specialties, affiliations and a list of published articles.
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Articles
45
Citations
706
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Recent Articles
11.
Colle M, Duyckaerts C, Laquerriere A, Pradier L, Czech C, Checler F, et al.
Neuropathol Appl Neurobiol
. 2000 Jun;
26(2):117-23.
PMID: 10840274
Presenilin 1 has been shown to be mutated in a high proportion of cases of familial Alzheimer's disease. Immunoreactive epitopes of the protein have been found mainly in neurones devoid...
12.
Czech C, Tremp G, Pradier L
Prog Neurobiol
. 2000 Feb;
60(4):363-84.
PMID: 10670705
Alzheimer's disease (AD) is the most common cause of dementia in the elderly population. Dementia is associated with massive accumulation of fibrillary aggregates in various cortical and subcortical regions of...
13.
Octave J, Essalmani R, Tasiaux B, Menager J, Czech C, Mercken L
J Biol Chem
. 2000 Jan;
275(3):1525-8.
PMID: 10636839
Presenilin-1 (PS1) is required for the release of the intracellular domain of Notch from the plasma membrane as well as for the cleavage of the amyloid precursor protein (APP) at...
14.
Dumanchin C, Czech C, Campion D, Cuif M, Poyot T, Martin C, et al.
Hum Mol Genet
. 1999 Jun;
8(7):1263-9.
PMID: 10369872
Presenilin 1 (PS1) mutations account for the majority of early-onset dominant cases of familial Alzheimer's disease. Presenilins (PSs) are located in many intra-cellular compartments such as the endoplasmic reticulum, Golgi...
15.
Li Q, Maynard C, Cappai R, McLean C, Cherny R, Lynch T, et al.
J Neurochem
. 1999 Jun;
72(6):2479-87.
PMID: 10349858
To study amyloid beta-protein (A beta) production and aggregation in vivo, we created two transgenic (Tg) mouse lines expressing the C-terminal 100 amino acids of human amyloid precursor protein (APP):...
16.
Pradier L, Carpentier N, Delalonde L, Clavel N, Bock M, Buee L, et al.
Neurobiol Dis
. 1999 Mar;
6(1):43-55.
PMID: 10078972
Mutations in presenilin 1 and presenilin 2 (PS1 and PS2, respectively) genes cause the large majority of familial forms of early-onset Alzheimer's disease. The physical interaction between presenilins and APP...
17.
Calenda A, Mestre-Frances N, Czech C, Pradier L, PETTER A, Perret M, et al.
Neurobiol Dis
. 1999 Mar;
5(5):323-33.
PMID: 10069575
A 1340-bp cDNA fragment encoding the lemurian presenilin 2 protein (PS2) was isolated from a Microcebus murinus brain cDNA library by PCR using oligonucleotide primers based on the nucleotide sequence...
18.
Fossgreen A, Bruckner B, Czech C, Masters C, Beyreuther K, Paro R
Proc Natl Acad Sci U S A
. 1998 Nov;
95(23):13703-8.
PMID: 9811864
The importance of the amyloid precursor protein (APP) in the pathogenesis of Alzheimer's disease (AD) became apparent through the identification of distinct mutations in the APP gene, causing early onset...
19.
Macq A, Czech C, Essalmani R, Brion J, Maron A, Mercken L, et al.
J Biol Chem
. 1998 Oct;
273(44):28931-6.
PMID: 9786896
Recombinant adenoviruses were used for the expression of human amyloid precursor protein (APP) of Alzheimer's disease in primary cultures of rat cortical neurons and astrocytes. The catabolic pathways of human...
20.
Czech C, Lesort M, Tremp G, Terro F, Blanchard V, Schombert B, et al.
Neuroscience
. 1998 Sep;
87(2):325-36.
PMID: 9740395
Mutations in the gene for presenilin 1 are causative for the majority of cases of early onset familial Alzheimer's disease. Yet, the physiological function of presenilin 1 and the pathological...