U Monning
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Explore the profile of U Monning including associated specialties, affiliations and a list of published articles.
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25
Citations
409
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Recent Articles
1.
Gelato K, Schockel L, Klingbeil O, Ruckert T, Lesche R, Toedling J, et al.
Oncogene
. 2017 Oct;
37(4):512-521.
PMID: 28991225
Metabolic changes are linked to epigenetic reprogramming and play important roles in several tumor types. PGC-1α is a transcriptional coactivator controlling mitochondrial biogenesis and is linked to oxidative phosphorylation. We...
2.
Hock C, Golombowski S, Muller-Spahn F, Naser W, Beyreuther K, Monning U, et al.
Eur Neurol
. 1998 Mar;
39(2):111-8.
PMID: 9520072
Alzheimer's disease (AD) is the most common neurodegenerative disorder characterized by progressive dementia that ultimately leads to death. Histopathological hallmarks of AD include brain amyloid deposits and neurofibrillary tangles. Major...
3.
Sandbrink R, Monning U, Masters C, Beyreuther K
Gerontology
. 1997 Jan;
43(1-2):119-31.
PMID: 8996834
The Alzheimer's beta A4-amyloid protein precursor (APP) and the APP-like proteins (APLPs) are transmembrane glycoproteins with a similar modular domain structure. Alternatively spliced exons found in both genes comprise a...
4.
Beyreuther K, Multhaup G, Monning U, Sandbrink R, Beher D, Hesse L, et al.
Ann N Y Acad Sci
. 1996 Jan;
777:74-6.
PMID: 8624129
We have identified and characterized the ligand binding properties of the Alzheimer's disease (AD) beta A4 amyloid protein precursor (APP), mapped the APP ligand binding sites and analyzed the regulation...
5.
Eckert A, Forstl H, Hartmann H, Czech C, Monning U, Beyreuther K, et al.
Neuroreport
. 1995 May;
6(8):1199-202.
PMID: 7662907
The amplifying effect of beta-amyloid fragment 25-35 (beta A25-35) on the mitogen-induced rise of free intracellular calcium in circulating lymphocytes was strongly reduced in 24 patients with Alzheimer's disease when...
6.
Simons M, Ikonen E, Tienari P, Monning U, Beyreuther K, Dotti C
J Neurosci Res
. 1995 May;
41(1):121-8.
PMID: 7674373
A characteristic neuropathological feature of Alzheimer's disease is the cerebral deposition of amyloid plaques. These deposits contain beta A4 amyloid peptide, a cleavage product of the transmembrane protein amyloid protein...
7.
Monning U, Sandbrink R, Weidemann A, Banati R, Masters C, Beyreuther K
J Biol Chem
. 1995 Mar;
270(13):7104-10.
PMID: 7706247
During axotomy studies, we discovered that the beta A4-amyloid precursor protein (APP) participates in immune responses of the central nervous system. Since microglia constitute the main immune effector cell population...
8.
Forstl H, Hentschel F, Sattel H, Besthorn C, Czech C, Monning U, et al.
Arzneimittelforschung
. 1995 Mar;
45(3A):394-7.
PMID: 7763332
A reliable and early diagnosis of incipient Alzheimer's disease (AD) is one of the obligatory requirements for timely and potentially successful therapeutic intervention. The potential diagnostic significance of mild cognitive...
9.
Forstl H, Czech C, Sattel H, Besthorn C, Kreger S, Monning U, et al.
Nervenarzt
. 1994 Nov;
65(11):780-6.
PMID: 7816155
The apolipoprotein E allele (Apo-E gene) status was determined in 147 individuals from a longitudinal study. 53 satisfied NINCDS-ADRDA criteria for probable or possible Alzheimer's disease (AD), 37 were non-demented...
10.
Dyrks T, Monning U, Beyreuther K, Turner J
FEBS Lett
. 1994 Aug;
349(2):210-4.
PMID: 8050568
The cellular factors regulating the generation of beta A4 from the amyloid precursor protein (APP) are unknown. Protein phosphorylation by protein kinase C (PKC) has been found to influence the...