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C A McQueen

Explore the profile of C A McQueen including associated specialties, affiliations and a list of published articles. Areas
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Articles 47
Citations 192
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Recent Articles
1.
Cao W, Chau B, Hunter R, Strnatka D, McQueen C, Erickson R
Pharmacogenomics J . 2005 Jul; 5(4):255-61. PMID: 16041393
Therapeutic and environmental aromatic amines and hydrazines are substrates for the arylamine N-acetyltransferases (NAT). In all, 10 transgenic lines containing either the human NAT1 or NAT2 transgene were developed using...
2.
Hein D, McQueen C, Grant D, Goodfellow G, Kadlubar F, Weber W
Drug Metab Dispos . 2000 Nov; 28(12):1425-32. PMID: 11095579
This article is a report on a symposium sponsored by the American Society for Pharmacology and Experimental Therapeutics presented at the joint meeting of the American Society for Biochemistry and...
3.
Burkey J, Sauer J, McQueen C, Sipes I
Mutat Res . 2000 Sep; 453(1):25-33. PMID: 11006409
Methyleugenol is a substituted alkenylbenzene found in a variety of foods, products, and essential oils. In a 2-year bioassay conducted by the National Toxicology Program, methyleugenol caused neoplastic lesions in...
4.
Stevens G, Burkey J, McQueen C
Cell Biol Toxicol . 2000 Jul; 16(1):31-9. PMID: 10890504
The heterocyclic amine, batracylin (BAT), is genotoxic and several lines of evidence suggest that acetylation is one step in the formation of a DNA-damaging product. The variation in susceptibility to...
5.
Dang L, McQueen C
Toxicol Appl Pharmacol . 1999 Sep; 159(2):77-82. PMID: 10495770
4-Aminobiphenyl (4-ABP), an aromatic amine present in tobacco smoke, is an animal and human carcinogen. 4-ABP can undergo several biotransformation reactions to yield DNA-binding species. The role of acetylation in...
6.
Stevens G, Payton M, Sim E, McQueen C
Drug Metab Dispos . 1999 Aug; 27(9):966-71. PMID: 10460792
Batracylin (8-aminoisoindolo[1,2-b]quinazolin-12(10 H)-one; BAT) is a heterocyclic amine that exhibits antitumor activity in a number of in vivo and in vitro models. The acetyl product has been implicated in BAT...
7.
Mitchell M, Futscher B, McQueen C
Drug Metab Dispos . 1999 Feb; 27(2):261-4. PMID: 9929513
N-Acetyltransferases (NATs) play an important role in the biotransformation of a wide variety of arylamine drugs and carcinogens. Two genes (NAT1, NAT2) have been identified and allelic variation in NAT2...
8.
Sauer J, Waalkes M, Hooser S, Kuester R, McQueen C, Sipes I
Toxicology . 1997 Aug; 121(2):155-64. PMID: 9230447
Exposure of humans to toxic metals and metalloids is a major environmental problem. Many metals, such as cadmium, can be hepatotoxic. However, the mechanisms by which metals cause acute hepatic...
9.
Poet T, McQueen C, Halpert J
Drug Metab Dispos . 1996 Jan; 24(1):74-80. PMID: 8825193
The contributions of cytochromes P4502B (P4502B) and cytochrome P4503A (P4503A) to the bioactivation of cocaine in hepatocytes isolated from Sprague-Dawley rats were assessed using a number of approaches. Hepatocytes were...
10.
Stevens G, LaVoie E, McQueen C
Carcinogenesis . 1996 Jan; 17(1):115-9. PMID: 8565119
The role of acetylation in the genotoxicity of the heterocyclic amine, batracylin, was evaluated in Salmonella typhimurium strains expressing various levels of N- and O-acetyltransferase activity. A significant correlation was...